129151-97-9Relevant articles and documents
Benzazepinone Calcium Channel Blockers. 3. Synthesis and Structure-Activity Studies of 3-Alkylbenzazepinones
Das, Jagabandhu,Floyd, David M.,Kimball, S. David,Duff, Keith J.,Vu, Truc Chi,et al.
, p. 773 - 780 (2007/10/02)
As part of a program aimed at identifying novel analogues of diltiazem, we developed several synthetic routes for 3-alkylbenzazepinones, both in racemic and nonracemic form.Structure-activity relationship studies in this series have led to identification
Benzazepinone calcium channel blockers. 4. Structure-activity overview and intracellular binding site
Kimball,Floyd,Das,Hunt,Krapcho,Rovnyak,Duff,Lee,Moquin,Turk,Hedberg,Moreland,Brittain,McMullen,Normandin,Cucinotta
, p. 780 - 793 (2007/10/02)
We have synthesized a series of benzazepinones (2) in order to determine the structure-activity relationships (SAR) for calcium channel blockers related to diltiazem. A prerequisite for calcium channel blocking activity in vitro and in vivo is the presenc
Benzazepine derivatives
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, (2008/06/13)
Vasodilating activity is exhibited by compounds having the formula STR1 and pharmaceutically acceptable salts thereof.