methyl (2S,3R)-2-(2-(2,5-bis(benzyloxy)-3-methoxy-4-methyl-6-nitrophenyl)-1-hydroxyethyl)-3-((4-methoxybenzyloxy)methyl)aziridine-1-carboxylate

Base Information

• Chemical Name: methyl (2S,3R)-2-(2-(2,5-bis(benzyloxy)-3-methoxy-4-methyl-6-nitrophenyl)-1-hydroxyethyl)-3-((4-methoxybenzyloxy)methyl)aziridine-1-carboxylate
• CAS No.: 1175522-90-3
• Molecular Formula: C₃₇H₄₀N₂O₁₀
• Molecular Weight: 672.732
• Mol file: 1175522-90-3.mol

Synonyms:methyl (2S,3R)-2-(2-(2,5-bis(benzyloxy)-3-methoxy-4-methyl-6-nitrophenyl)-1-hydroxyethyl)-3-((4-methoxybenzyloxy)methyl)aziridine-1-carboxylate

Chemical Property of methyl (2S,3R)-2-(2-(2,5-bis(benzyloxy)-3-methoxy-4-methyl-6-nitrophenyl)-1-hydroxyethyl)-3-((4-methoxybenzyloxy)methyl)aziridine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2S,3R)-2-(2-(2,5-bis(benzyloxy)-3-methoxy-4-methyl-6-nitrophenyl)-1-hydroxyethyl)-3-((4-methoxybenzyloxy)methyl)aziridine-1-carboxylate

There total 1 articles about methyl (2S,3R)-2-(2-(2,5-bis(benzyloxy)-3-methoxy-4-methyl-6-nitrophenyl)-1-hydroxyethyl)-3-((4-methoxybenzyloxy)methyl)aziridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-methoxy-3,6-dimethyl-5-nitrohydroquinone dibenzyl ether (100827-55-2) + (2S-cis)-methyl ester 2-formyl-3-[(4-methoxyphenyl)methoxymethyl]-1-aziridinecarboxylic acid (192061-03-3) → methyl (2S,3R)-2-(2-(2,5-bis(benzyloxy)-3-methoxy-4-methyl-6-nitrophenyl)-1-hydroxyethyl)-3-((4-methoxybenzyloxy)methyl)aziridine-1-carboxylate (1175522-90-3)

Guidance literature:

(2S-cis)-methyl ester 2-formyl-3-[(4-methoxyphenyl)methoxymethyl]-1-aziridinecarboxylic acid; With zinc(II) chloride; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

2-methoxy-3,6-dimethyl-5-nitrohydroquinone dibenzyl ether; With sodium hexamethyldisilazane; In N,N-dimethyl-formamide; at -45 ℃; for 3h;

With water; ammonium chloride; In N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2009.05.004

Reference yield: 98.0%

methyl (2S,3R)-2-(2-(2,5-bis(benzyloxy)-3-methoxy-4-methyl-6-nitrophenyl)-1-hydroxyethyl)-3-((4-methoxybenzyloxy)methyl)aziridine-1-carboxylate (1175522-90-3) → methyl (2S,3R)-2-(2-(2,5-bis(benzyloxy)-3-methoxy-4-methyl-6-nitrophenyl)acetyl)-3-((4-methoxybenzyloxy)methyl)aziridine-1-carboxylate (1175522-73-2)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2009.05.004

upstream raw materials:

2-methoxy-3,6-dimethyl-5-nitrohydroquinone dibenzyl ether

(2S-cis)-methyl ester 2-formyl-3-[(4-methoxyphenyl)methoxymethyl]-1-aziridinecarboxylic acid

Downstream raw materials:

methyl (2S,3R)-2-(2-(2,5-bis(benzyloxy)-3-methoxy-4-methyl-6-nitrophenyl)acetyl)-3-((4-methoxybenzyloxy)methyl)aziridine-1-carboxylate