(2R,3R)-3-acetylthio-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butyl acetate

Base Information

• Chemical Name: (2R,3R)-3-acetylthio-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butyl acetate
• CAS No.: 145942-95-6
• Molecular Formula: C₁₆H₁₇F₂N₃O₃S
• Molecular Weight: 369.392
• Mol file: 145942-95-6.mol

Synonyms:(2R,3R)-3-acetylthio-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butyl acetate

Chemical Property of (2R,3R)-3-acetylthio-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-3-acetylthio-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butyl acetate

There total 2 articles about (2R,3R)-3-acetylthio-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1-[1H-1,2,4-triazol-1-yl]-2-butanol (135272-34-3) + 1-ethyl-2-(hydroxymethyl)-1H-imidazole (63634-44-6) → (2R,3R)-3-acetylthio-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butyl acetate (145942-95-6)

Guidance literature:

With pyridine; dmap; at 80 ℃; for 20h;

DOI:10.1248/cpb.42.85

Reference yield:

dmap (1122-58-3) + silica gel + (2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1-[1H-1,2,4-triazol-1-yl]-2-butanol (135272-34-3) → (2R,3R)-3-acetylthio-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butyl acetate (145942-95-6)

Guidance literature:

With pyridine; acetic anhydride; In ethyl acetate;

Reference yield: 72.0%

(2R,3R)-3-acetylthio-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butyl acetate (145942-95-6) → (2R,3R)-3-acetoxy-3-(2,4-difluorophenyl)-4-(1H-1,2,4-triazol-1-yl)-2-butanesulfonyl chloride (145942-96-7)

Guidance literature:

With chlorine; acetic acid; at 5 ℃; for 3h;

DOI:10.1248/cpb.42.85

upstream raw materials:

(2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1-[1H-1,2,4-triazol-1-yl]-2-butanol

1-ethyl-2-(hydroxymethyl)-1H-imidazole

dmap

Downstream raw materials:

(2R,3R)-3-acetoxy-3-(2,4-difluorophenyl)-4-(1H-1,2,4-triazol-1-yl)-2-butanesulfonyl chloride