Technology Process of 2-Methyl-4-phenyl-2-azabicyclo<2.2.2>octan
There total 9 articles about 2-Methyl-4-phenyl-2-azabicyclo<2.2.2>octan which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 7h;
Heating;
DOI:10.1002/ardp.19803130603
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 55 percent / p-toluenesulfonic acid / CH2Cl2 / 24 h / Heating
2: 96 percent / NaNH2 / dimethylsulfoxide / 1 h / 50 °C
3: 77 percent / KOH / ethane-1,2-diol; H2O / 48 h / Heating
4: 92 percent / acetic acid / 24 h / Heating
5: 1.) NaOH / 1.) EtOH, HMPT, 10 min, 2.) 50 deg C, 2 h
6: 51.6 percent / H2 / PtO2 / H2O; methanol / Ambient temperature
7: 90 percent / NaOMe / methanol / 24 h / Heating
8: 80 percent / LiALH4 / tetrahydrofuran / 7 h / Heating
With
potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; hydrogen; sodium methylate; toluene-4-sulfonic acid; sodium amide; acetic acid;
platinum(IV) oxide;
In
tetrahydrofuran; methanol; dichloromethane; water; ethylene glycol; dimethyl sulfoxide;
DOI:10.1002/ardp.19803130603
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 96 percent / NaNH2 / dimethylsulfoxide / 1 h / 50 °C
2: 77 percent / KOH / ethane-1,2-diol; H2O / 48 h / Heating
3: 92 percent / acetic acid / 24 h / Heating
4: 1.) NaOH / 1.) EtOH, HMPT, 10 min, 2.) 50 deg C, 2 h
5: 51.6 percent / H2 / PtO2 / H2O; methanol / Ambient temperature
6: 90 percent / NaOMe / methanol / 24 h / Heating
7: 80 percent / LiALH4 / tetrahydrofuran / 7 h / Heating
With
potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; hydrogen; sodium methylate; sodium amide; acetic acid;
platinum(IV) oxide;
In
tetrahydrofuran; methanol; water; ethylene glycol; dimethyl sulfoxide;
DOI:10.1002/ardp.19803130603