1-((2-Bromophenyl)sulfonyl)-5-methoxy-3-((4-methylpiperazin-1-yl)methyl)-1H-indole

Base Information

Chemical Name:1-((2-Bromophenyl)sulfonyl)-5-methoxy-3-((4-methylpiperazin-1-yl)methyl)-1H-indole
CAS No.:701205-60-9
Molecular Formula:C₂₁H₂₄BrN₃O₃S
Molecular Weight:478.41
Hs Code.:
UNII:8XZ281AO3G
NCI Thesaurus Code:C175121
Metabolomics Workbench ID:149636
ChEMBL ID:CHEMBL4117187

Synonyms:1-((2-bromophenyl)sulfonyl)-5-methoxy-3-((4-methyl-1-piperazinyl)methyl)-1H-indole dimesylate monohydrate;SUVN-502

Suppliers and Price of 1-((2-Bromophenyl)sulfonyl)-5-methoxy-3-((4-methylpiperazin-1-yl)methyl)-1H-indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 1-((2-Bromophenyl)sulfonyl)-5-methoxy-3-((4-methylpiperazin-1-yl)methyl)-1H-indole

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:477.07218
Heavy Atom Count:29
Complexity:650

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1CCN(CC1)CC2=CN(C3=C2C=C(C=C3)OC)S(=O)(=O)C4=CC=CC=C4Br
Recent ClinicalTrials:SUVN-502 With Donepezil and Memantine for the Treatment of Moderate Alzheimer's Disease- Phase 2a Study
Recent EU Clinical Trials:A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Parallel Group, Multicenter Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Masupirdine (SUVN-502) for the Treatment of Agitation in Participants with Dementia of the Alzheimer's Type

Technology Process of 1-((2-Bromophenyl)sulfonyl)-5-methoxy-3-((4-methylpiperazin-1-yl)methyl)-1H-indole

There total 5 articles about 1-((2-Bromophenyl)sulfonyl)-5-methoxy-3-((4-methylpiperazin-1-yl)methyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 701205-15-4
5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole

: 2905-25-1
o-bromobenzenesulfonyl chloride

: 701205-60-9
1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; at 15 - 20 ℃;
DOI:10.1016/j.bmcl.2018.04.014

Reference yield:

: 109-01-3
1-methyl-piperazine

: 701205-60-9
1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / water / 5 - 20 °C / Large scale

1.2: 3 h / 15 - 30 °C / Large scale

2.1: methanol / 8 - 35 °C / Large scale

3.1: potassium hydroxide / tetrahydrofuran / 1.17 h / 10 - 35 °C / Large scale

3.2: 5.42 h / 10 - 35 °C / Large scale

With acetic acid; potassium hydroxide; In tetrahydrofuran; methanol; water; 1.1: |Mannich Aminomethylation;

Reference yield:

: 1-(2-hydroxymethyl)-4-methylpiperazine

: 701205-60-9
1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 8 - 35 °C / Large scale

2.1: potassium hydroxide / tetrahydrofuran / 1.17 h / 10 - 35 °C / Large scale

2.2: 5.42 h / 10 - 35 °C / Large scale

With potassium hydroxide; In tetrahydrofuran; methanol;