1-(3-(tert-butyldimethylsilyloxy)propyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one

Base Information

Chemical Name:1-(3-(tert-butyldimethylsilyloxy)propyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one
CAS No.:1335247-90-9
Molecular Formula:C₂₀H₃₁NO₂Si
Molecular Weight:345.557
Hs Code.:

Synonyms:1-(3-(tert-butyldimethylsilyloxy)propyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3-(tert-butyldimethylsilyloxy)propyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one

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Technology Process of 1-(3-(tert-butyldimethylsilyloxy)propyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one

There total 1 articles about 1-(3-(tert-butyldimethylsilyloxy)propyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 89031-84-5
3-(tert-butyldimethylsilyloxy)propyl bromide

: 126378-84-5
(RS)-2-phenyl-2,3-dihydro-1H-pyridin-4-one

: 1335247-90-9
1-(3-(tert-butyldimethylsilyloxy)propyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol202202a

Reference yield: 75.0%

: 1335247-90-9
1-(3-(tert-butyldimethylsilyloxy)propyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one

: 780-69-8
triethoxyphenylsilane

: 1335247-98-7
N-(3'-((tert-butyldimethylsilyl)oxy)propyl)-2,5-diphenyl-2,3-dihydropyridin-4(1H)-one

Guidance literature:: 1-(3-(tert-butyldimethylsilyloxy)propyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one; With palladium diacetate; In acetic acid; tert-butyl alcohol; at 65 ℃; for 0.25h;

triethoxyphenylsilane; With copper (II)-fluoride; In acetic acid; tert-butyl alcohol; at 20 - 65 ℃; for 3.5h;
DOI:10.1021/ol202202a

Reference yield: 45.0%

: 696-62-8
para-iodoanisole

: 1335247-90-9
1-(3-(tert-butyldimethylsilyloxy)propyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one

: 1443017-99-9
1-(3-((tert-butyldimethylsilyl)oxy)propyl)-5-(4-methoxyphenyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one

Guidance literature:: With tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate; silver(I) chloride; In dimethyl sulfoxide; at 80 ℃; for 24h; regioselective reaction;
DOI:10.1021/jo400830t