2-((2R,4S,6S)-4-(2-bromoethoxy)-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethanone

Base Information

Chemical Name:2-((2R,4S,6S)-4-(2-bromoethoxy)-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethanone
CAS No.:1449418-09-0
Molecular Formula:C₂₁H₂₃BrO₃
Molecular Weight:403.316
Hs Code.:

Synonyms:2-((2R,4S,6S)-4-(2-bromoethoxy)-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethanone

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Chemical Property of 2-((2R,4S,6S)-4-(2-bromoethoxy)-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethanone

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Technology Process of 2-((2R,4S,6S)-4-(2-bromoethoxy)-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethanone

There total 6 articles about 2-((2R,4S,6S)-4-(2-bromoethoxy)-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1449417-66-6
(E)-3-(3-(2-bromoethoxy)-4-iodo-1-phenylbutoxy)-1-phenylprop-2-en-1-one

: 1449418-09-0
2-((2R,4S,6S)-4-(2-bromoethoxy)-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethanone

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 0.0833333h; Reflux; Inert atmosphere;
DOI:10.1016/j.tet.2013.05.081

Reference yield:

: 1449418-05-6
C₂₀H₂₂BrIN₄O₂S

: 1449418-09-0
2-((2R,4S,6S)-4-(2-bromoethoxy)-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / ethyl acetate / 1 h / 20 °C

2: tributylphosphine / dichloromethane / 1.25 h / 0 °C / Inert atmosphere

3: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / benzene / 0.08 h / Reflux; Inert atmosphere

With 2,2'-azobis(isobutyronitrile); tributylphosphine; tri-n-butyl-tin hydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; ethyl acetate; benzene;
DOI:10.1016/j.tet.2013.05.081

Reference yield:

: 1449417-64-4
(1S,3R)-3-(2-bromoethoxy)-4-iodo-1-phenylbutan-1-ol

: 1449418-09-0
2-((2R,4S,6S)-4-(2-bromoethoxy)-6-phenyltetrahydro-2H-pyran-2-yl)-1-phenylethanone

Guidance literature:: Multi-step reaction with 2 steps

1: tributylphosphine / dichloromethane / 1.25 h / 0 °C / Inert atmosphere

2: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / benzene / 0.08 h / Reflux; Inert atmosphere

With 2,2'-azobis(isobutyronitrile); tributylphosphine; tri-n-butyl-tin hydride; In dichloromethane; benzene;
DOI:10.1016/j.tet.2013.05.081