(E)-3-(3-(2-bromoethoxy)-4-iodo-1-phenylbutoxy)-1-phenylprop-2-en-1-one

Base Information

Chemical Name:(E)-3-(3-(2-bromoethoxy)-4-iodo-1-phenylbutoxy)-1-phenylprop-2-en-1-one
CAS No.:1449417-66-6
Molecular Formula:C₂₁H₂₂BrIO₃
Molecular Weight:529.212
Hs Code.:

Synonyms:(E)-3-(3-(2-bromoethoxy)-4-iodo-1-phenylbutoxy)-1-phenylprop-2-en-1-one

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Chemical Property of (E)-3-(3-(2-bromoethoxy)-4-iodo-1-phenylbutoxy)-1-phenylprop-2-en-1-one

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Technology Process of (E)-3-(3-(2-bromoethoxy)-4-iodo-1-phenylbutoxy)-1-phenylprop-2-en-1-one

There total 4 articles about (E)-3-(3-(2-bromoethoxy)-4-iodo-1-phenylbutoxy)-1-phenylprop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1449417-64-4
(1S,3R)-3-(2-bromoethoxy)-4-iodo-1-phenylbutan-1-ol

: 3623-15-2
phenyl propargyl ketone

: 1449417-66-6
(E)-3-(3-(2-bromoethoxy)-4-iodo-1-phenylbutoxy)-1-phenylprop-2-en-1-one

Guidance literature:: With tributylphosphine; In dichloromethane; at 0 ℃; for 1.25h; Inert atmosphere;
DOI:10.1016/j.tet.2013.05.081

Reference yield:

: 77118-87-7,936-58-3
(S)-1-Phenyl-3-buten-1-ol

: 1449417-66-6
(E)-3-(3-(2-bromoethoxy)-4-iodo-1-phenylbutoxy)-1-phenylprop-2-en-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: N-iodo-succinimide / nitromethane / 6 h / 2 °C / Darkness; Inert atmosphere

3: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / ethyl acetate / 1 h / 20 °C

4: tributylphosphine / dichloromethane / 1.25 h / 0 °C / Inert atmosphere

With N-iodo-succinimide; tributylphosphine; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In nitromethane; dichloromethane; ethyl acetate;
DOI:10.1016/j.tet.2013.05.081

Reference yield:

: 1449418-05-6
C₂₀H₂₂BrIN₄O₂S

: 1449417-66-6
(E)-3-(3-(2-bromoethoxy)-4-iodo-1-phenylbutoxy)-1-phenylprop-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / ethyl acetate / 1 h / 20 °C

2: tributylphosphine / dichloromethane / 1.25 h / 0 °C / Inert atmosphere

With tributylphosphine; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; ethyl acetate;
DOI:10.1016/j.tet.2013.05.081