methyl 2-[(tert-butoxycarbonyl)amino]-4-nitrobenzoate

Base Information

• Chemical Name: methyl 2-[(tert-butoxycarbonyl)amino]-4-nitrobenzoate
• CAS No.: 147291-59-6
• Molecular Formula: C₁₃H₁₆N₂O₆
• Molecular Weight: 296.28
• Mol file: 147291-59-6.mol

Synonyms:methyl 2-[(tert-butoxycarbonyl)amino]-4-nitrobenzoate

Chemical Property of methyl 2-[(tert-butoxycarbonyl)amino]-4-nitrobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 2-[(tert-butoxycarbonyl)amino]-4-nitrobenzoate

There total 2 articles about methyl 2-[(tert-butoxycarbonyl)amino]-4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

di-tert-butyl dicarbonate (24424-99-5) + methyl 2-amino-4-nitrobenzoate (3558-19-8) → methyl 2-[(tert-butoxycarbonyl)amino]-4-nitrobenzoate (147291-59-6)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.05.018

Reference yield:

4-Nitroanthranilic acid (619-17-0) → methyl 2-[(tert-butoxycarbonyl)amino]-4-nitrobenzoate (147291-59-6)

Guidance literature:

Multi-step reaction with 2 steps

2: DMAP / CH₂Cl₂ / 16 h / Heating

With dmap; In dichloromethane;

DOI:10.1021/jm980166z

Reference yield: 88.0%

methyl 2-[(tert-butoxycarbonyl)amino]-4-nitrobenzoate (147291-59-6) → methyl 4-amino-2-[(tert-butoxycarbonyl)amino]benzoate (232282-37-0)

Guidance literature:

With palladium 10% on activated carbon; ammonium formate; In methanol; at 65 ℃; for 0.25h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.tetlet.2015.05.018

upstream raw materials:

di-tert-butyl dicarbonate

methyl 2-amino-4-nitrobenzoate

4-Nitroanthranilic acid

Downstream raw materials:

methyl 4-amino-2-[(tert-butoxycarbonyl)amino]benzoate

N-(tert-butoxycarbonyl)-4-(carbobenzyloxyamino)-2-aminobenzoic acid methyl ester