N-(tert-butoxycarbonyl)-4-(carbobenzyloxyamino)-2-aminobenzoic acid methyl ester

Base Information

• Chemical Name: N-(tert-butoxycarbonyl)-4-(carbobenzyloxyamino)-2-aminobenzoic acid methyl ester
• CAS No.: 147291-60-9
• Molecular Formula: C₂₁H₂₄N₂O₆
• Molecular Weight: 400.431
• Mol file: 147291-60-9.mol

Synonyms:N-(tert-butoxycarbonyl)-4-(carbobenzyloxyamino)-2-aminobenzoic acid methyl ester

Chemical Property of N-(tert-butoxycarbonyl)-4-(carbobenzyloxyamino)-2-aminobenzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-(tert-butoxycarbonyl)-4-(carbobenzyloxyamino)-2-aminobenzoic acid methyl ester

There total 5 articles about N-(tert-butoxycarbonyl)-4-(carbobenzyloxyamino)-2-aminobenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → N-(tert-butoxycarbonyl)-4-(carbobenzyloxyamino)-2-aminobenzoic acid methyl ester (147291-60-9)

Guidance literature:

Multi-step reaction with 3 steps

1: DMAP / CH₂Cl₂ / 16 h / Heating

2: H₂ / 5 percent Pd/C / methanol / 4 h / 2585.74 Torr

With dmap; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jm980166z

Reference yield:

4-Nitroanthranilic acid (619-17-0) → N-(tert-butoxycarbonyl)-4-(carbobenzyloxyamino)-2-aminobenzoic acid methyl ester (147291-60-9)

Guidance literature:

Multi-step reaction with 4 steps

2: DMAP / CH₂Cl₂ / 16 h / Heating

3: H₂ / 5 percent Pd/C / methanol / 4 h / 2585.74 Torr

With dmap; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jm980166z

Reference yield:

methyl 2-[(tert-butoxycarbonyl)amino]-4-nitrobenzoate (147291-59-6) → N-(tert-butoxycarbonyl)-4-(carbobenzyloxyamino)-2-aminobenzoic acid methyl ester (147291-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 5 percent Pd/C / methanol / 4 h / 2585.74 Torr

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jm980166z

upstream raw materials:

benzyl chloroformate

methyl 4-amino-2-[(tert-butoxycarbonyl)amino]benzoate

di-tert-butyl dicarbonate

4-Nitroanthranilic acid