(4-{2-[4-((E)-6-iodohex-5-enyloxy)phenyl]ethyl}-2-methyl-4,5-dihydrooxazol-4-yl)methanol

Base Information

Chemical Name:(4-{2-[4-((E)-6-iodohex-5-enyloxy)phenyl]ethyl}-2-methyl-4,5-dihydrooxazol-4-yl)methanol
CAS No.:1301696-62-7
Molecular Formula:C₁₉H₂₆INO₃
Molecular Weight:443.325
Hs Code.:

Synonyms:(4-{2-[4-((E)-6-iodohex-5-enyloxy)phenyl]ethyl}-2-methyl-4,5-dihydrooxazol-4-yl)methanol

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Chemical Property of (4-{2-[4-((E)-6-iodohex-5-enyloxy)phenyl]ethyl}-2-methyl-4,5-dihydrooxazol-4-yl)methanol

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Technology Process of (4-{2-[4-((E)-6-iodohex-5-enyloxy)phenyl]ethyl}-2-methyl-4,5-dihydrooxazol-4-yl)methanol

There total 3 articles about (4-{2-[4-((E)-6-iodohex-5-enyloxy)phenyl]ethyl}-2-methyl-4,5-dihydrooxazol-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 791097-48-8
(R/S)-4-[2-(4-hydroxymethyl-2-methyl-4,5-dihydro-oxazol-4-yl)-ethyl]-phenol

: 201035-80-5
(E)-6-iodohex-5-en-1-ol

: 1301696-62-7
(4-{2-[4-((E)-6-iodohex-5-enyloxy)phenyl]ethyl}-2-methyl-4,5-dihydrooxazol-4-yl)methanol

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 - 50 ℃; for 114h;
DOI:10.1002/cmdc.201000477

Reference yield:

: 73448-13-2
tert-butyldimethylsilyl hex-5-yn-1-yl ether

: 1301696-62-7
(4-{2-[4-((E)-6-iodohex-5-enyloxy)phenyl]ethyl}-2-methyl-4,5-dihydrooxazol-4-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: zirconocene dichloride; lithium triethylborohydride / tetrahydrofuran / 0.5 h / 20 °C

1.2: 3 h / 20 °C

2.1: methanol; acetyl chloride / diethyl ether / 61 h / 0 - 20 °C

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 114 h / 20 - 50 °C

With methanol; zirconocene dichloride; di-isopropyl azodicarboxylate; lithium triethylborohydride; acetyl chloride; triphenylphosphine; In tetrahydrofuran; diethyl ether; 3.1: Mitsunobu reaction;
DOI:10.1002/cmdc.201000477

Reference yield:

: 132260-33-4
(E)-1-iodo-6-<(tert-butyldimethylsilyl)oxy>-1-hexene

: 1301696-62-7
(4-{2-[4-((E)-6-iodohex-5-enyloxy)phenyl]ethyl}-2-methyl-4,5-dihydrooxazol-4-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; acetyl chloride / diethyl ether / 61 h / 0 - 20 °C

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 114 h / 20 - 50 °C

With methanol; di-isopropyl azodicarboxylate; acetyl chloride; triphenylphosphine; In tetrahydrofuran; diethyl ether; 2: Mitsunobu reaction;
DOI:10.1002/cmdc.201000477