5-(4-chlorophenyl)-2-mercapto-7-phenylpyrido[2,3-d]pyrimidin-4(3H)-one

Base Information

• Chemical Name: 5-(4-chlorophenyl)-2-mercapto-7-phenylpyrido[2,3-d]pyrimidin-4(3H)-one
• CAS No.: 150356-88-0
• Molecular Formula: C₁₉H₁₂ClN₃OS
• Molecular Weight: 365.843

Synonyms:5-(4-chlorophenyl)-2-mercapto-7-phenylpyrido[2,3-d]pyrimidin-4(3H)-one

Chemical Property of 5-(4-chlorophenyl)-2-mercapto-7-phenylpyrido[2,3-d]pyrimidin-4(3H)-one

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Technology Process of 5-(4-chlorophenyl)-2-mercapto-7-phenylpyrido[2,3-d]pyrimidin-4(3H)-one

There total 2 articles about 5-(4-chlorophenyl)-2-mercapto-7-phenylpyrido[2,3-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

carbon disulfide (75-15-0,12122-00-8) + 2-amino-3-carboxamido-4-(4-chlorophenyl)-6-phenylpyridine → 5-(4-chlorophenyl)-2-mercapto-7-phenylpyrido[2,3-d]pyrimidin-4(3H)-one (150356-88-0)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 155 ℃; for 0.25h; Microwave irradiation;

DOI:10.1515/hc-2012-0131

Reference yield: 85.0%

3-(4-chlorophenyl)-1-phenylprop-2-en-1-one (956-04-7) + 6-Amino-2-thiouracil (1004-40-6) → 5-(4-chlorophenyl)-2,3-dihydro-7-phenyl-2-thioxopyrido<2,3-d>pyrimidin-4(1H)-one (150356-88-0)

Guidance literature:

With air; In N,N-dimethyl-formamide; for 15h; Heating;

DOI:10.1002/jhet.5570290502

Reference yield: 70.0%

5-(4-chlorophenyl)-2,3-dihydro-7-phenyl-2-thioxopyrido<2,3-d>pyrimidin-4(1H)-one (150356-88-0) → 5-(4-chlorophenyl)-2-hydrazino-7-phenylpyrido[2,3-d]pyrimidin-4(3H)-one (1310089-65-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 15h; Reflux;

DOI:10.1016/j.ejmech.2011.02.055

upstream raw materials:

3-(4-chlorophenyl)-1-phenylprop-2-en-1-one

6-Amino-2-thiouracil

carbon disulfide

Downstream raw materials:

ethyl [6-(4-chlorophenyl)-5-oxo-8-phenyl-1H-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-3-ylsulphanyl]acetate

6-(4-chlorophenyl)-3,8-diphenyl-1H-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one

6-(4-chlorophenyl)-3-(4-methylphenyl)-8-phenyl-1H-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one

3,6-di(4-chlorophenyl)-8-phenyl-1H-pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one

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