cis-Piperidine-2,3-dicarboxylic acid

Base Information

• Chemical Name: cis-Piperidine-2,3-dicarboxylic acid
• CAS No.: 46026-75-9
• Molecular Formula: C₇H₁₁NO₄
• Molecular Weight: 173.169
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID80963487
• Nikkaji Number: J263.752I
• ChEMBL ID: CHEMBL431504
• Mol file: 46026-75-9.mol

Synonyms:2,3-piperidine dicarboxylate;2,3-piperidinedicarboxylic acid;cis-2,3-piperidine dicarboxylic acid

Chemical Property of cis-Piperidine-2,3-dicarboxylic acid

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.52
• Boiling Point: 419.413 °C at 760 mmHg
• Flash Point: 207.454 °C
• PSA: 86.63000
• Density: 1.364 g/cm³
• LogP: -0.14740
• Storage Temp.: +2C to +8C
• Solubility.: H2O: ≥15 mg/mL
• XLogP3: -2.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 173.06880783
• Heavy Atom Count: 12
• Complexity: 204

Purity/Quality:

99% ^*data from raw suppliers

2,3 cis-Piperidine dicarboxylic acid - CAS 46026-75-9 - Calbiochem ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(C(NC1)C(=O)O)C(=O)O
• Isomeric SMILES: C1C[C@H]([C@H](NC1)C(=O)O)C(=O)O
• Uses: 2,3-Piperidinedicarboxylic Acid acts as an antagonist of excitatory amino acids in the hippocampus. It is also reported that 2,3-Piperidinedicarboxylic Acid is shown to be neurotoxic and produce highly significant alterations in the physical state of membrane proteins.

Technology Process of cis-Piperidine-2,3-dicarboxylic acid

There total 7 articles about cis-Piperidine-2,3-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Pyridine-2,3-dicarboxylic acid (89-00-9) → cis-2,3-piperidinedicarboxylic acid (82949-15-3,46026-75-9,84211-43-8) + pipecolic Acid (4043-87-2,83680-83-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; Yield given. Yields of byproduct given;

DOI:10.3987/com-97-s77

Reference yield:

Pyridine-2,3-dicarboxylic acid (89-00-9) + aluminium hydride (7784-21-6) + nickel (7440-02-0) → piperidine-2,3-dicarboxylic acid (17079-18-4,46026-75-9,84211-43-8)

Guidance literature:

In sodium hydroxide;

Reference yield:

→ trans-2,3-piperidinedicarboxylic acid (84229-42-5,46026-75-9,84211-43-8)

Guidance literature:

With sodium pentanolate;

upstream raw materials:

Pyridine-2,3-dicarboxylic acid

aluminium hydride

nickel

Refernces

• 1、 -. "HETEROCYCLIC-NMDA ANTAGONISTS". . . Retrieved 2008/06/13.