N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-(2-((S)-acetylamino-2-carboxy)ethyl))phenyl phosphorodiamidate

Base Information

Chemical Name:N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-(2-((S)-acetylamino-2-carboxy)ethyl))phenyl phosphorodiamidate
CAS No.:898291-08-2
Molecular Formula:C₂₁H₂₈ClN₄O₈P
Molecular Weight:530.902
Hs Code.:

Synonyms:N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-(2-((S)-acetylamino-2-carboxy)ethyl))phenyl phosphorodiamidate

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Chemical Property of N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-(2-((S)-acetylamino-2-carboxy)ethyl))phenyl phosphorodiamidate

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Technology Process of N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-(2-((S)-acetylamino-2-carboxy)ethyl))phenyl phosphorodiamidate

There total 6 articles about N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-(2-((S)-acetylamino-2-carboxy)ethyl))phenyl phosphorodiamidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₃₂ClN₄O₈P

: 898291-08-2
N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-(2-((S)-acetylamino-2-carboxy)ethyl))phenyl phosphorodiamidate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium 4-methylbenzenesulfinate; In tetrahydrofuran; at 20 ℃; for 0.75h;
DOI:10.1021/jm060142p

Reference yield:

: 17363-92-7
N-acetyl-4-nitro-L-phenylalanine

: 898291-08-2
N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-(2-((S)-acetylamino-2-carboxy)ethyl))phenyl phosphorodiamidate

Guidance literature:: Multi-step reaction with 5 steps

1.1: H₂ / Pd/C / ethanol / 1 h / 3102.89 Torr

2.1: 3.6 g / H₂SO₄ / 2 h / Heating

3.1: diisopropylethylamine; POCl₃ / CH₂Cl₂ / 0.17 h / -5 °C

3.2: 33 percent / diisopropylethylamine / CH₂Cl₂ / 3 h / -5 - 20 °C

4.1: LiHMDS / tetrahydrofuran / 4 h / -20 °C

5.1: 0.29 g / aq. sodium p-toluenesulfinate; Pd(PPh₃)4 / tetrahydrofuran / 0.75 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; hydrogen; sodium 4-methylbenzenesulfinate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm060142p

Reference yield:

: 949-99-5
4-nitro-3-phenyl-L-alanine

: 898291-08-2
N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-(2-((S)-acetylamino-2-carboxy)ethyl))phenyl phosphorodiamidate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 74 percent / aq. NaOH / acetone / 1 h

2.1: H₂ / Pd/C / ethanol / 1 h / 3102.89 Torr

3.1: 3.6 g / H₂SO₄ / 2 h / Heating

4.1: diisopropylethylamine; POCl₃ / CH₂Cl₂ / 0.17 h / -5 °C

4.2: 33 percent / diisopropylethylamine / CH₂Cl₂ / 3 h / -5 - 20 °C

5.1: LiHMDS / tetrahydrofuran / 4 h / -20 °C

6.1: 0.29 g / aq. sodium p-toluenesulfinate; Pd(PPh₃)4 / tetrahydrofuran / 0.75 h / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; hydrogen; sodium 4-methylbenzenesulfinate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetone;
DOI:10.1021/jm060142p