N-methyl-N-(4-chlorobutyl) N'-(4-(2-((S)-acetylamino-2-carboxyallyl)ethyl))phenyl phosphorodiamidic chloride

Base Information

Chemical Name:N-methyl-N-(4-chlorobutyl) N'-(4-(2-((S)-acetylamino-2-carboxyallyl)ethyl))phenyl phosphorodiamidic chloride
CAS No.:898291-06-0
Molecular Formula:C₁₉H₂₈Cl₂N₃O₄P
Molecular Weight:464.329
Hs Code.:

Synonyms:N-methyl-N-(4-chlorobutyl) N'-(4-(2-((S)-acetylamino-2-carboxyallyl)ethyl))phenyl phosphorodiamidic chloride

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Chemical Property of N-methyl-N-(4-chlorobutyl) N'-(4-(2-((S)-acetylamino-2-carboxyallyl)ethyl))phenyl phosphorodiamidic chloride

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Technology Process of N-methyl-N-(4-chlorobutyl) N'-(4-(2-((S)-acetylamino-2-carboxyallyl)ethyl))phenyl phosphorodiamidic chloride

There total 4 articles about N-methyl-N-(4-chlorobutyl) N'-(4-(2-((S)-acetylamino-2-carboxyallyl)ethyl))phenyl phosphorodiamidic chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 898291-04-8
N-acetyl-4-amino-L-phenylalanine allyl ester

: N-methyl-N-(4-chloro-n-butyl)amine hydrochloride

: 898291-06-0
N-methyl-N-(4-chlorobutyl) N'-(4-(2-((S)-acetylamino-2-carboxyallyl)ethyl))phenyl phosphorodiamidic chloride

Guidance literature:: N-acetyl-4-amino-L-phenylalanine allyl ester; With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; at -5 ℃; for 0.166667h;

N-methyl-N-(4-chloro-n-butyl)amine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -5 - 20 ℃; for 3h;
DOI:10.1021/jm060142p

Reference yield:

: 17363-92-7
N-acetyl-4-nitro-L-phenylalanine

: 898291-06-0
N-methyl-N-(4-chlorobutyl) N'-(4-(2-((S)-acetylamino-2-carboxyallyl)ethyl))phenyl phosphorodiamidic chloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂ / Pd/C / ethanol / 1 h / 3102.89 Torr

2.1: 3.6 g / H₂SO₄ / 2 h / Heating

3.1: diisopropylethylamine; POCl₃ / CH₂Cl₂ / 0.17 h / -5 °C

3.2: 33 percent / diisopropylethylamine / CH₂Cl₂ / 3 h / -5 - 20 °C

With sulfuric acid; hydrogen; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm060142p

Reference yield:

: 949-99-5
4-nitro-3-phenyl-L-alanine

: 898291-06-0
N-methyl-N-(4-chlorobutyl) N'-(4-(2-((S)-acetylamino-2-carboxyallyl)ethyl))phenyl phosphorodiamidic chloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: 74 percent / aq. NaOH / acetone / 1 h

2.1: H₂ / Pd/C / ethanol / 1 h / 3102.89 Torr

3.1: 3.6 g / H₂SO₄ / 2 h / Heating

4.1: diisopropylethylamine; POCl₃ / CH₂Cl₂ / 0.17 h / -5 °C

4.2: 33 percent / diisopropylethylamine / CH₂Cl₂ / 3 h / -5 - 20 °C

With sodium hydroxide; sulfuric acid; hydrogen; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium on activated charcoal; In ethanol; dichloromethane; acetone;
DOI:10.1021/jm060142p