(2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-2-pentyl-piperidine-2-carbonitrile

Base Information

Chemical Name:(2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-2-pentyl-piperidine-2-carbonitrile
CAS No.:87168-83-0
Molecular Formula:C₂₃H₃₄N₂O₂
Molecular Weight:370.535
Hs Code.:

Synonyms:(2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-2-pentyl-piperidine-2-carbonitrile

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Chemical Property of (2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-2-pentyl-piperidine-2-carbonitrile

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Technology Process of (2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-2-pentyl-piperidine-2-carbonitrile

There total 9 articles about (2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-2-pentyl-piperidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6302-02-9
2-acetonylpyridine

: 87168-83-0
(2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-2-pentyl-piperidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

3: NaBH₄ / methanol

4: m-CPBA / CH₂Cl₂ / 0.17 h / Ambient temperature

5: 1.) (CF₃CO)2O / 1.) CH₂Cl₂, -10 deg C, 20 min. 2.) room temp., 1 h, pH 4

6: 95 percent / Hydrogen / 10percent Pd/C / ethanol / 3 h

7: LDA / 1.) THF, -20 deg C, 20 min. 2.) 2 h

With sodium tetrahydroborate; hydrogen; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; lithium diisopropyl amide; palladium on activated charcoal; In methanol; ethanol; dichloromethane;
DOI:10.1016/S0040-4039(00)81854-7

Reference yield:

: 87168-79-4
1-Benzyl-2-(2-methyl-[1,3]dioxolan-2-ylmethyl)-1,2,3,6-tetrahydro-pyridine

: 87168-83-0
(2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-2-pentyl-piperidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: m-CPBA / CH₂Cl₂ / 0.17 h / Ambient temperature

2: 1.) (CF₃CO)2O / 1.) CH₂Cl₂, -10 deg C, 20 min. 2.) room temp., 1 h, pH 4

3: 95 percent / Hydrogen / 10percent Pd/C / ethanol / 3 h

4: LDA / 1.) THF, -20 deg C, 20 min. 2.) 2 h

With hydrogen; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; lithium diisopropyl amide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/S0040-4039(00)81854-7

Reference yield:

: 87168-80-7
(2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-1,2,5,6-tetrahydro-pyridine-2-carbonitrile

: 87168-83-0
(2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-2-pentyl-piperidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / Hydrogen / 10percent Pd/C / ethanol / 3 h

2: LDA / 1.) THF, -20 deg C, 20 min. 2.) 2 h

With hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In ethanol;
DOI:10.1016/S0040-4039(00)81854-7