(2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-piperidine-2-carbonitrile

Base Information

Chemical Name:(2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-piperidine-2-carbonitrile
CAS No.:87168-81-8
Molecular Formula:C₁₈H₂₄N₂O₂
Molecular Weight:300.401
Hs Code.:

Synonyms:(2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-piperidine-2-carbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-piperidine-2-carbonitrile

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Technology Process of (2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-piperidine-2-carbonitrile

There total 7 articles about (2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-piperidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 87168-80-7
(2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-1,2,5,6-tetrahydro-pyridine-2-carbonitrile

: 87168-81-8
(2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-piperidine-2-carbonitrile

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 3h;
DOI:10.1016/S0040-4039(00)81854-7

Reference yield:

: 6302-02-9
2-acetonylpyridine

: 87168-81-8
(2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-piperidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

3: NaBH₄ / methanol

4: m-CPBA / CH₂Cl₂ / 0.17 h / Ambient temperature

5: 1.) (CF₃CO)2O / 1.) CH₂Cl₂, -10 deg C, 20 min. 2.) room temp., 1 h, pH 4

6: 95 percent / Hydrogen / 10percent Pd/C / ethanol / 3 h

With sodium tetrahydroborate; hydrogen; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; palladium on activated charcoal; In methanol; ethanol; dichloromethane;
DOI:10.1016/S0040-4039(00)81854-7

Reference yield:

: 87168-79-4
1-Benzyl-2-(2-methyl-[1,3]dioxolan-2-ylmethyl)-1,2,3,6-tetrahydro-pyridine

: 87168-81-8
(2S,6S)-1-Benzyl-6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-piperidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: m-CPBA / CH₂Cl₂ / 0.17 h / Ambient temperature

2: 1.) (CF₃CO)2O / 1.) CH₂Cl₂, -10 deg C, 20 min. 2.) room temp., 1 h, pH 4

3: 95 percent / Hydrogen / 10percent Pd/C / ethanol / 3 h

With hydrogen; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/S0040-4039(00)81854-7