4-[(tert-Butoxycarbonyl-phenethyl-amino)-methyl]-3-nitro-benzoic acid tert-butyl ester

Base Information

• Chemical Name: 4-[(tert-Butoxycarbonyl-phenethyl-amino)-methyl]-3-nitro-benzoic acid tert-butyl ester
• CAS No.: 147290-83-3
• Molecular Formula: C₂₅H₃₂N₂O₆
• Molecular Weight: 456.539

Synonyms:4-[(tert-Butoxycarbonyl-phenethyl-amino)-methyl]-3-nitro-benzoic acid tert-butyl ester

Chemical Property of 4-[(tert-Butoxycarbonyl-phenethyl-amino)-methyl]-3-nitro-benzoic acid tert-butyl ester

Chemical Property:

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Technology Process of 4-[(tert-Butoxycarbonyl-phenethyl-amino)-methyl]-3-nitro-benzoic acid tert-butyl ester

There total 3 articles about 4-[(tert-Butoxycarbonyl-phenethyl-amino)-methyl]-3-nitro-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-Nitro-4-(phenethylamino-methyl)-benzoic acid tert-butyl ester (147290-82-2) → 4-[(tert-Butoxycarbonyl-phenethyl-amino)-methyl]-3-nitro-benzoic acid tert-butyl ester (147290-83-3)

Guidance literature:

DOI:10.1021/ja00072a058

Reference yield:

2-nitro-4-(tert-butoxycarbonyl)benzyl bromide (65276-90-6) → 4-[(tert-Butoxycarbonyl-phenethyl-amino)-methyl]-3-nitro-benzoic acid tert-butyl ester (147290-83-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent

2: 85 percent

DOI:10.1021/ja00072a058

Reference yield:

phenethylamine (64-04-0) → 4-[(tert-Butoxycarbonyl-phenethyl-amino)-methyl]-3-nitro-benzoic acid tert-butyl ester (147290-83-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent

2: 85 percent

DOI:10.1021/ja00072a058

upstream raw materials:

di-tert-butyl dicarbonate

3-Nitro-4-(phenethylamino-methyl)-benzoic acid tert-butyl ester

2-nitro-4-(tert-butoxycarbonyl)benzyl bromide

phenethylamine

Downstream raw materials:

[8-(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-acetic acid methyl ester

2-{5-tert-Butoxycarbonyl-2-[(tert-butoxycarbonyl-phenethyl-amino)-methyl]-phenylamino}-succinic acid dimethyl ester

(Z)-2-{5-tert-Butoxycarbonyl-2-[(tert-butoxycarbonyl-phenethyl-amino)-methyl]-phenylamino}-but-2-enedioic acid dimethyl ester

methyl (R,S)-8-[[[4-(aminoiminomethyl)phenyl]amino]-carbonyl]-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate

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