2-((R)-(3-chlorophenyl)((R)-piperidin-3-yl)methoxy)ethanol hydrochloride

Base Information

• Chemical Name: 2-((R)-(3-chlorophenyl)((R)-piperidin-3-yl)methoxy)ethanol hydrochloride
• CAS No.: 942145-65-5
• Molecular Formula: C₁₄H₂₀ClNO₂*ClH
• Molecular Weight: 306.232
• Mol file: 942145-65-5.mol

Synonyms:2-((R)-(3-chlorophenyl)((R)-piperidin-3-yl)methoxy)ethanol hydrochloride

Chemical Property of 2-((R)-(3-chlorophenyl)((R)-piperidin-3-yl)methoxy)ethanol hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-((R)-(3-chlorophenyl)((R)-piperidin-3-yl)methoxy)ethanol hydrochloride

There total 1 articles about 2-((R)-(3-chlorophenyl)((R)-piperidin-3-yl)methoxy)ethanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-tert-butyl 3-((R)-(2-(tert-butyldimethylsilyloxy)ethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate (1240123-62-9) → 2-((R)-(3-chlorophenyl)((R)-piperidin-3-yl)methoxy)ethanol hydrochloride (942145-65-5)

Guidance literature:

With hydrogenchloride; water; In acetonitrile; at 20 ℃; for 48h;

Reference yield:

2-((R)-(3-chlorophenyl)((R)-piperidin-3-yl)methoxy)ethanol hydrochloride (942145-65-5) + 4-nitrophenyl (S)-(3-cyclohexyl-1-((2-(trimethylsilyl)ethylcarbamate)methylamino)propan-2-yl)carbamate (884511-70-0) → 2-(trimethylsilyl)ethyl (S)-2-((R)-3-((R)-(3-chlorophenyl)(2-hydroxyethoxy)methyl)piperidine-1-carboxamido)-3-cyclohexylpropyl(methyl)carbamate (942144-81-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 17h;

upstream raw materials:

(R)-tert-butyl 3-((R)-(2-(tert-butyldimethylsilyloxy)ethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate

Downstream raw materials:

2-(trimethylsilyl)ethyl (S)-2-((R)-3-((R)-(3-chlorophenyl)(2-hydroxyethoxy)methyl)piperidine-1-carboxamido)-3-cyclohexylpropyl(methyl)carbamate