Tyrosinamide, L-leucyl-a,b-didehydro-N-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3-hydroxy-,(aZ)- (9CI)

Base Information

Chemical Name:Tyrosinamide, L-leucyl-a,b-didehydro-N-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3-hydroxy-,(aZ)- (9CI)
CAS No.:115982-34-8
Molecular Formula:C₂₃H₂₇N₃O₆
Molecular Weight:441.484
Hs Code.:

Synonyms:Tyrosinamide,L-leucyl-a,b-didehydro-N-[2-(3,4-dihydroxyphenyl)ethenyl]-3-hydroxy-,(E,Z)-; Tunichrome Mm 2

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Tyrosinamide, L-leucyl-a,b-didehydro-N-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3-hydroxy-,(aZ)- (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Tyrosinamide, L-leucyl-a,b-didehydro-N-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3-hydroxy-,(aZ)- (9CI)

There total 14 articles about Tyrosinamide, L-leucyl-a,b-didehydro-N-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-3-hydroxy-,(aZ)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99815-16-4
3,4-bis(tert-butyldimethylsilanyloxy)benzaldehyde

: 115982-34-8
Tunichrome Mm-2

Guidance literature:: Multi-step reaction with 12 steps

1: 100 percent / ZnI₂

2: LiAlH₄ / tetrahydrofuran

3: CH₂Cl₂

4: 75 percent / n-Bu₃P / tetrahydrofuran

5: 100 percent / 30percent TFA / CH₂Cl₂

6: 85 percent / DCC / CH₂Cl₂

7: 78 percent / H₂O₂, pyridine / tetrahydrofuran

8: 100 percent / TFA / CH₂Cl₂

9: 75 percent

10: 1) LDA / 1) THF 2) hν, hexane

11: TFA / CH₂Cl₂ / 1 h / Ambient temperature

12: 48percent aq. HF, pyridine / 6 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; tributylphosphine; hydrogen fluoride; dihydrogen peroxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc(II) iodide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)97256-3

Reference yield:

: 139-85-5
3,4-dihydroxybenzaldehyde

: 115982-34-8
Tunichrome Mm-2

Guidance literature:: Multi-step reaction with 13 steps

1: 98 percent / imidazole / CH₂Cl₂

2: 100 percent / ZnI₂

3: LiAlH₄ / tetrahydrofuran

4: CH₂Cl₂

5: 75 percent / n-Bu₃P / tetrahydrofuran

6: 100 percent / 30percent TFA / CH₂Cl₂

7: 85 percent / DCC / CH₂Cl₂

8: 78 percent / H₂O₂, pyridine / tetrahydrofuran

9: 100 percent / TFA / CH₂Cl₂

10: 75 percent

11: 1) LDA / 1) THF 2) hν, hexane

12: TFA / CH₂Cl₂ / 1 h / Ambient temperature

13: 48percent aq. HF, pyridine / 6 h / Ambient temperature

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; tributylphosphine; hydrogen fluoride; dihydrogen peroxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc(II) iodide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)97256-3

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 115982-34-8
Tunichrome Mm-2

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent

2: 1) LDA / 1) THF 2) hν, hexane

3: TFA / CH₂Cl₂ / 1 h / Ambient temperature

4: 48percent aq. HF, pyridine / 6 h / Ambient temperature

With pyridine; hydrogen fluoride; trifluoroacetic acid; lithium diisopropyl amide; In dichloromethane;
DOI:10.1016/S0040-4039(00)97256-3