(E)-2,4-diamino-5-[2-(2'-methoxyphenyl)prop-1-enyl]furo[2,3-d]pyrimidine

Base Information

Chemical Name:(E)-2,4-diamino-5-[2-(2'-methoxyphenyl)prop-1-enyl]furo[2,3-d]pyrimidine
CAS No.:862822-92-2
Molecular Formula:C₁₆H₁₆N₄O₂
Molecular Weight:296.329
Hs Code.:

Synonyms:(E)-2,4-diamino-5-[2-(2'-methoxyphenyl)prop-1-enyl]furo[2,3-d]pyrimidine

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Chemical Property of (E)-2,4-diamino-5-[2-(2'-methoxyphenyl)prop-1-enyl]furo[2,3-d]pyrimidine

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Technology Process of (E)-2,4-diamino-5-[2-(2'-methoxyphenyl)prop-1-enyl]furo[2,3-d]pyrimidine

There total 3 articles about (E)-2,4-diamino-5-[2-(2'-methoxyphenyl)prop-1-enyl]furo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 579-74-8
2-Methoxyacetophenone

: 67194-86-9
5-(chloromethyl)furo[2,3-d]pyrimidine-2,4-diamine

: 862822-92-2
(E)-2,4-diamino-5-[2-(2'-methoxyphenyl)prop-1-enyl]furo[2,3-d]pyrimidine

: 1196852-22-8
(Z)-5-(2-(2-methoxyphenyl)prop-1-enyl)furo[2,3-d]pyrimidine-2,4-diamine

Guidance literature:: 5-(chloromethyl)furo[2,3-d]pyrimidine-2,4-diamine; With tributylphosphine; In dimethyl sulfoxide; at 60 ℃; for 3h; Inert atmosphere;

2-Methoxyacetophenone; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2009.08.044

Reference yield:

: 579-74-8
2-Methoxyacetophenone

: tributyl-(2,4-diamino-furo[2,3-d]pyrimidin-5-ylmethyl)-phosphonium; chloride

: 862822-92-2
(E)-2,4-diamino-5-[2-(2'-methoxyphenyl)prop-1-enyl]furo[2,3-d]pyrimidine

Guidance literature:: In dimethyl sulfoxide; at 20 ℃; for 32h;
DOI:10.1016/j.bmc.2005.04.087

Reference yield:

: 67194-86-9
5-(chloromethyl)furo[2,3-d]pyrimidine-2,4-diamine

: 862822-92-2
(E)-2,4-diamino-5-[2-(2'-methoxyphenyl)prop-1-enyl]furo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylsulfoxide / 3 h / 60 °C

2: 350 mg / dimethylsulfoxide / 32 h / 20 °C

In dimethyl sulfoxide; 2: Wittig reaction;
DOI:10.1016/j.bmc.2005.04.087