5-(CHLOROMETHYL)FURO[2,3-D]PYRIMIDINE-2,4-DIAMINE

Base Information

• Chemical Name: 5-(CHLOROMETHYL)FURO[2,3-D]PYRIMIDINE-2,4-DIAMINE
• CAS No.: 67194-86-9
• Molecular Formula: C7H7ClN4O
• Molecular Weight: 198.61000
• Mol file: 67194-86-9.mol

Synonyms:(+-)-5-Chlor-4-hydroxy-valeriansaeure-lacton;5-Chlormethyl-dihydro-furan-2-on;5-(chloromethyl)dihydro-2(3H)-furanone;2,4-diamino-5-chloromethylfuro[2,3-d]pyrimidine;5-chloromethyl-furo[2,3-d]pyrimidine-2,4-diamine;5-(chloromethyl)dihydrofuran-2(3h)-one;5-chloromethyl-dihydro-furan-2-one;

Chemical Property of 5-(CHLOROMETHYL)FURO[2,3-D]PYRIMIDINE-2,4-DIAMINE

Chemical Property:

• PSA: 90.96000
• LogP: 2.28840

Purity/Quality:

97% ^*data from raw suppliers

5-(CHLOROMETHYL)FURO[2,3-D]PYRIMIDINE-2,4-DIAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(CHLOROMETHYL)FURO[2,3-D]PYRIMIDINE-2,4-DIAMINE

There total 2 articles about 5-(CHLOROMETHYL)FURO[2,3-D]PYRIMIDINE-2,4-DIAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,6-diamino-3H-pyrimidin-4-one (100643-27-4,143504-99-8) + 1,3-Dichloroacetone (534-07-6) → 5-(chloromethyl)furo[2,3-d]pyrimidine-2,4-diamine (67194-86-9)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1021/jm010575m

Reference yield: 53.0%

1,3-Dichloroacetone (534-07-6) + 2,6-diaminopyrimidin-4-ol (56-06-4) → 5-(chloromethyl)furo[2,3-d]pyrimidine-2,4-diamine (67194-86-9)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1002/jhet.5570370442

Reference yield: 68.0%

5-(chloromethyl)furo[2,3-d]pyrimidine-2,4-diamine (67194-86-9) + diethyl N-<4-(methylamino)benzoyl>-L-glutamate (2378-95-2) → diethyl N-<4-pyrimidin-5-yl)methyl>methylamino>benzoyl>-L-glutamate

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 40 ℃; for 72h;

DOI:10.1021/jm00034a015

upstream raw materials:

2,6-diamino-3H-pyrimidin-4-one

1,3-Dichloroacetone

2,6-diaminopyrimidin-4-ol

Downstream raw materials:

N-<4-pyrimidin-5-yl)methyl>amino>benzoyl>-L-glutamic acid

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