methyl 2-hydroxy-5-((2S,6R)-6-(4-hydroxyphenylethyl)-5,6-dihydro-2H-pyran-2-yl)benzoate

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Chemical Name:methyl 2-hydroxy-5-((2S,6R)-6-(4-hydroxyphenylethyl)-5,6-dihydro-2H-pyran-2-yl)benzoate
CAS No.:1288996-90-6
Molecular Formula:C₂₁H₂₂O₅
Molecular Weight:354.403
Hs Code.:

Synonyms:methyl 2-hydroxy-5-((2S,6R)-6-(4-hydroxyphenylethyl)-5,6-dihydro-2H-pyran-2-yl)benzoate

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Chemical Property of methyl 2-hydroxy-5-((2S,6R)-6-(4-hydroxyphenylethyl)-5,6-dihydro-2H-pyran-2-yl)benzoate

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Technology Process of methyl 2-hydroxy-5-((2S,6R)-6-(4-hydroxyphenylethyl)-5,6-dihydro-2H-pyran-2-yl)benzoate

There total 2 articles about methyl 2-hydroxy-5-((2S,6R)-6-(4-hydroxyphenylethyl)-5,6-dihydro-2H-pyran-2-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1288996-79-1
methyl 5-((2S,6R)-6-(4-(tert-butyldimethylsilyloxy)phenylethyl)-5,6-dihydro-2H-pyran-2-yl)-2-hydroxybenzoate

: 1288996-90-6
methyl 2-hydroxy-5-((2S,6R)-6-(4-hydroxyphenylethyl)-5,6-dihydro-2H-pyran-2-yl)benzoate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jo2002787

Reference yield:

: 1202784-98-2
(R)-2-[4-(tert-butyldimethylsilyloxy)phenethyl]-3,4-dihydro-2H-pyran

: 1261270-09-0
4-hydroxy-3-(methoxycarbonyl)benzenediazonium tetrafluoroborate

: 1288996-90-6
methyl 2-hydroxy-5-((2S,6R)-6-(4-hydroxyphenylethyl)-5,6-dihydro-2H-pyran-2-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium acetate; palladium diacetate / acetonitrile / 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; sodium acetate; palladium diacetate; In tetrahydrofuran; acetonitrile; 1: Mizoroki-Heck reaction;
DOI:10.1021/jo2002787