(S)-diethyl 3-((S)-4-benzyl-2-oxooxazolidin-3-ylamino)-2,2-dimethylsuccinate

Base Information

Chemical Name:(S)-diethyl 3-((S)-4-benzyl-2-oxooxazolidin-3-ylamino)-2,2-dimethylsuccinate
CAS No.:740808-79-1
Molecular Formula:C₂₀H₂₈N₂O₆
Molecular Weight:392.452
Hs Code.:

Synonyms:(S)-diethyl 3-((S)-4-benzyl-2-oxooxazolidin-3-ylamino)-2,2-dimethylsuccinate

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Chemical Property of (S)-diethyl 3-((S)-4-benzyl-2-oxooxazolidin-3-ylamino)-2,2-dimethylsuccinate

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Technology Process of (S)-diethyl 3-((S)-4-benzyl-2-oxooxazolidin-3-ylamino)-2,2-dimethylsuccinate

There total 3 articles about (S)-diethyl 3-((S)-4-benzyl-2-oxooxazolidin-3-ylamino)-2,2-dimethylsuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 31469-16-6
1-ethoxy-1-((trimethylsilyl)oxy)-2-methylpropene

: 575465-38-2
ethyl 2-{[(4S)-4-benzyl-2-oxo-1,3-dioxolan-2-yl]imino}acetate

: 740808-79-1
(S)-diethyl 3-((S)-4-benzyl-2-oxooxazolidin-3-ylamino)-2,2-dimethylsuccinate

Guidance literature:: With zinc(II) chloride; In acetonitrile; at 20 ℃; for 44h;
DOI:10.1021/jo0358170

Reference yield:

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: 740808-79-1
(S)-diethyl 3-((S)-4-benzyl-2-oxooxazolidin-3-ylamino)-2,2-dimethylsuccinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: O-(p-nitrobenzoyl)hydroxylamine; NaH / dioxane

1.2: 78 percent / p-TsOH / toluene

2.1: 54 percent / ZnCl₂ / acetonitrile / 44 h / 20 °C

With O-(4-nitrobenzoyl) hydroxylamine; sodium hydride; zinc(II) chloride; In 1,4-dioxane; acetonitrile;
DOI:10.1021/jo0358170

Reference yield:

: 31469-16-6
1-ethoxy-1-((trimethylsilyl)oxy)-2-methylpropene

: 575465-38-2
ethyl 2-{[(4S)-4-benzyl-2-oxo-1,3-dioxolan-2-yl]imino}acetate

: (R)-diethyl 3-((S)-4-benzyl-2-oxooxazolidin-3-ylamino)-2,2-dimethylsuccinate

: 740808-79-1
(S)-diethyl 3-((S)-4-benzyl-2-oxooxazolidin-3-ylamino)-2,2-dimethylsuccinate

Guidance literature:: With zinc trifluoromethanesulfonate; In acetonitrile; at 20 ℃; for 44h; Further Variations:; Reagents; Product distribution;
DOI:10.1021/jo0358170