2,4-dichloro-5-(5-methyl-1,3,4-oxadiazol-2-yl)benzenesulfonamide

Base Information

• Chemical Name: 2,4-dichloro-5-(5-methyl-1,3,4-oxadiazol-2-yl)benzenesulfonamide
• CAS No.: 1380545-53-8
• Molecular Formula: C₉H₇Cl₂N₃O₃S
• Molecular Weight: 308.145
• Mol file: 1380545-53-8.mol

Synonyms:2,4-dichloro-5-(5-methyl-1,3,4-oxadiazol-2-yl)benzenesulfonamide

Chemical Property of 2,4-dichloro-5-(5-methyl-1,3,4-oxadiazol-2-yl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-dichloro-5-(5-methyl-1,3,4-oxadiazol-2-yl)benzenesulfonamide

There total 4 articles about 2,4-dichloro-5-(5-methyl-1,3,4-oxadiazol-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2,4-dichloro-5-(carbazoyl)benzenesulfonamide (18648-15-2) + Triethyl orthoacetate (78-39-7) → 2,4-dichloro-5-(5-methyl-1,3,4-oxadiazol-2-yl)benzenesulfonamide (1380545-53-8)

Guidance literature:

In acetic acid; Reflux;

DOI:10.1007/s00706-012-0732-6

Reference yield:

2,4-dichloro-5-sulfamoylbenzoic acid (2736-23-4) → 2,4-dichloro-5-(5-methyl-1,3,4-oxadiazol-2-yl)benzenesulfonamide (1380545-53-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: thionyl chloride / 4 h / Reflux

2.1: Reflux

2.2: 1 h

3.1: hydrazine hydrate / ethanol / 4 h / Reflux

4.1: acetic acid / Reflux

With thionyl chloride; hydrazine hydrate; acetic acid; In ethanol;

DOI:10.1016/j.ejmech.2014.05.039

Reference yield:

2,4-dichloro-5-sulphamylbenzoyl chloride (3740-16-7) → 2,4-dichloro-5-(5-methyl-1,3,4-oxadiazol-2-yl)benzenesulfonamide (1380545-53-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Reflux

1.2: 1 h

2.1: hydrazine hydrate / ethanol / 4 h / Reflux

3.1: acetic acid / Reflux

With hydrazine hydrate; acetic acid; In ethanol;

DOI:10.1016/j.ejmech.2014.05.039

upstream raw materials:

2,4-dichloro-5-(carbazoyl)benzenesulfonamide

Triethyl orthoacetate

2,4-dichloro-5-sulfamoylbenzoic acid

methyl 2,4-dichloro-5-sulfamoyl-benzoate

Downstream raw materials:

2-benzylthio-4-chloro-5-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(thien-2-ylcarbonyl)benzenesulfonamide

2-benzylthio-4-chloro-5-(5-methyl-1,3,4-oxadiazol-2-yl)-benzenesulfonamide

4-chloro-2-(4-chlorobenzylthio)-5-(5-methyl-1,3,4-oxadiazol-2-yl)benzenesulfonamide

4-chloro-2-(4-chlorobenzylthio)-5-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(thien-2-ylcarbonyl)benzenesulfonamide