3740-16-7Relevant academic research and scientific papers
Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV
Mickevi?iūt?, Aurelija,Timm, David D.,Gedgaudas, Marius,Linkuvien?, Vaida,Chen, Zhiwei,Waheed, Abdul,Michailovien?, Vilma,Zubrien?, Asta,Smirnov, Alexey,?apkauskait?, Edita,Baranauskien?, Lina,Jachno, Jelena,Revuckien?, Jurgita,Manakova, Elena,Gra?ulis, Saulius,Matulien?, Jurgita,Di Cera, Enrico,Sly, William S.,Matulis, Daumantas
, p. 271 - 290 (2018)
Membrane-associated carbonic anhydrase (CA) isoform IV participates in carbon metabolism and pH homeostasis and is implicated in the development of eye diseases such as retinitis pigmentosa and glaucoma. A series of substituted benzenesulfonamides were de
Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases
Zak?auskas, Audrius,?apkauskait?, Edita,Jezep?ikas, Linas,Linkuvien?, Vaida,Ki?onait?, Migl?,Smirnov, Alexey,Manakova, Elena,Gra?ulis, Saulius,Matulis, Daumantas
, p. 61 - 78 (2018/07/06)
Rational design of compounds that would bind specific pockets of the target proteins is a difficult task in drug design. The 12 isoforms of catalytically active human carbonic anhydrases (CAs) have highly similar active sites that make it difficult to des
SELECTIVE INHIBITORS OF CARBONIC ANHYDRASE
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Page/Page column 24, (2017/02/24)
Invention is related to novel compounds – benzenesulfonamides of general formulas (I) and (II). The compounds can be used in biomedicine as active ingredients in pharmaceutical formulations, because they inhibit enzymes which participate in disease progre
Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes i and II and the transmembrane tumor-associated isozymes IX and XII
S?awiński, Jaros?aw,Pogorzelska, Aneta,Zo?nowska, Beata,Brozewicz, Kamil,Vullo, Daniela,Supuran, Claudiu T.
, p. 47 - 55 (2014/06/10)
A series of novel 5-substituted 2,4-dichlorobenzenesulfonamides 5a-c, 6a-d, 7a-j and 10a-i have been synthesized and investigated as inhibitors of four isoforms of zinc enzyme carbonic anhydrase (CA.EC 4.2.1.1), that is the cytosolic CA I and II, and tumo
