(S)-2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>-1-butylamine

Base Information

Chemical Name:(S)-2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>-1-butylamine
CAS No.:159497-82-2
Molecular Formula:C₂₄H₃₈N₂OSi
Molecular Weight:398.664
Hs Code.:

Synonyms:(S)-2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>-1-butylamine

Suppliers and Price of (S)-2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>-1-butylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>-1-butylamine

Chemical Property:

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Technology Process of (S)-2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>-1-butylamine

There total 7 articles about (S)-2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>-1-butylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 152299-02-0
(S)-1-<2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>-N-phthalimide

: 159497-82-2
(S)-2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>-1-butylamine

Guidance literature:: With hydrazine hydrate; In ethanol; for 16h; Heating;
DOI:10.1021/jo00101a042

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 159497-82-2
(S)-2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>-1-butylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / imidazole / dimethylformamide / 2 h / 0 °C

2: 94 percent / MesCl, Et₃N / CH₂Cl₂ / 1.) 0 deg C, 5 min, 2.) 1 h

3: 52 percent / tetrahydrofuran / 48 h / 50 °C

4: 95 percent / hydrazine hydrate / ethanol / 16 h / Heating

With 1H-imidazole; hydrazine hydrate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00101a042

Reference yield:

: 137428-32-1
(2S)-2-[bis(phenylmethyl)amino]-1,4-butanediol

: 159497-82-2
(S)-2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>-1-butylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / imidazole / dimethylformamide / 2 h / 0 °C

2: 94 percent / MesCl, Et₃N / CH₂Cl₂ / 1.) 0 deg C, 5 min, 2.) 1 h

3: 52 percent / tetrahydrofuran / 48 h / 50 °C

4: 95 percent / hydrazine hydrate / ethanol / 16 h / Heating

With 1H-imidazole; hydrazine hydrate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00101a042