tert-butyl 4-[N-[2-acetoxymethyl-7-chloro-4-oxo-3,4-dihydroxyquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate

Base Information

Chemical Name:tert-butyl 4-[N-[2-acetoxymethyl-7-chloro-4-oxo-3,4-dihydroxyquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate
CAS No.:289687-01-0
Molecular Formula:C₂₆H₂₆ClN₃O₅
Molecular Weight:495.963
Hs Code.:

Synonyms:tert-butyl 4-[N-[2-acetoxymethyl-7-chloro-4-oxo-3,4-dihydroxyquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate

Suppliers and Price of tert-butyl 4-[N-[2-acetoxymethyl-7-chloro-4-oxo-3,4-dihydroxyquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 4-[N-[2-acetoxymethyl-7-chloro-4-oxo-3,4-dihydroxyquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 4-[N-[2-acetoxymethyl-7-chloro-4-oxo-3,4-dihydroxyquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate

There total 9 articles about tert-butyl 4-[N-[2-acetoxymethyl-7-chloro-4-oxo-3,4-dihydroxyquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 112888-76-3
tert-butyl p-[N-(prop-2-ynyl)amino]benzoate

: 289687-00-9
2-acetoxymethyl-6-bromomethyl-7-chloro-3,4-dihydroquinazolin-4-one

: 289687-01-0
tert-butyl 4-[N-[2-acetoxymethyl-7-chloro-4-oxo-3,4-dihydroxyquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate

Guidance literature:: With 2,6-dimethylpyridine; In N,N-dimethyl-formamide; at 120 ℃; for 16h;
DOI:10.1021/jm011081s

Reference yield:

: 95-74-9,827571-80-2
3-chloro-p-toluidine

: 289687-01-0
tert-butyl 4-[N-[2-acetoxymethyl-7-chloro-4-oxo-3,4-dihydroxyquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate

Guidance literature:: Multi-step reaction with 9 steps

1: 86 percent / pyridine / ethyl acetate / 18 h / 20 °C

2: 48 percent / glacial AcOH; Br₂ / 1.5 h / 15 °C

3: 94 percent / AcOH; conc. HCl / 24 h / 118 °C

4: 6.52 g / N-methylpyrrolidinone / 2 h / 163 °C

5: 93 percent / aq. KOH; H₂O₂ / 2 h / 130 °C

6: 69 percent / Na / methanol / 2 h / 20 °C

7: 87 percent / dimethylformamide / 2.25 h / 85 °C

8: 40 percent / NBS; dibenzoyl peroxide / CCl₄ / 3.5 h / 120 °C / Irradiation

9: 48 percent / 2,6-lutidine / dimethylformamide / 16 h / 120 °C

With pyridine; 2,6-dimethylpyridine; 1-methyl-pyrrolidin-2-one; hydrogenchloride; potassium hydroxide; N-Bromosuccinimide; dihydrogen peroxide; bromine; sodium; acetic acid; dibenzoyl peroxide; In methanol; tetrachloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm011081s

Reference yield:

: 7149-79-3
N-(3-chloro-4-methylphenyl)acetamide

: 289687-01-0
tert-butyl 4-[N-[2-acetoxymethyl-7-chloro-4-oxo-3,4-dihydroxyquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate

Guidance literature:: Multi-step reaction with 8 steps

1: 48 percent / glacial AcOH; Br₂ / 1.5 h / 15 °C

2: 94 percent / AcOH; conc. HCl / 24 h / 118 °C

3: 6.52 g / N-methylpyrrolidinone / 2 h / 163 °C

4: 93 percent / aq. KOH; H₂O₂ / 2 h / 130 °C

5: 69 percent / Na / methanol / 2 h / 20 °C

6: 87 percent / dimethylformamide / 2.25 h / 85 °C

7: 40 percent / NBS; dibenzoyl peroxide / CCl₄ / 3.5 h / 120 °C / Irradiation

8: 48 percent / 2,6-lutidine / dimethylformamide / 16 h / 120 °C

With 2,6-dimethylpyridine; 1-methyl-pyrrolidin-2-one; hydrogenchloride; potassium hydroxide; N-Bromosuccinimide; dihydrogen peroxide; bromine; sodium; acetic acid; dibenzoyl peroxide; In methanol; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm011081s