112888-76-3

Usage

Uses

Used in Organic Synthesis:
Tert-Butyl 4-(2-propynylamino)benzoate is utilized as a building block in organic synthesis for its ability to participate in various chemical reactions, making it a key component in the creation of pharmaceuticals and agrochemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, tert-Butyl 4-(2-propynylamino)benzoate is used as a versatile intermediate for the synthesis of biologically active compounds, capitalizing on its reactivity and structural features to develop new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, tert-Butyl 4-(2-propynylamino)benzoate serves as a crucial intermediate, contributing to the development of new agrochemicals that can enhance crop protection and yield.
Used in Material Science:
Tert-Butyl 4-(2-propynylamino)benzoate may also find applications in material science, where it could be employed as a precursor for the synthesis of new materials with unique properties, owing to its structural attributes and synthetic potential.
Used as a Precursor in Chemical Research:
In the realm of chemical research, tert-Butyl 4-(2-propynylamino)benzoate is used as a precursor to explore novel synthetic pathways and discover new compounds with potential applications in various fields.

InChI:InChI=1/C14H17NO2/c1-5-10-15-12-8-6-11(7-9-12)13(16)17-14(2,3)4/h1,6-9,15H,10H2,2-4H3

Upstream product

• 18144-47-3 tert-butyl 4-aminobenzoate 
• 106-96-7 propargyl bromide 
• 1262414-95-8 O-t-butyl 4-(trifluoroacetamido)benzoate 

Downstream Products

• 112888-77-4 tert-butyl 4--N-prop-2-ynylamino>benzoate 
• 172793-48-5 tert-butyl 4--N-prop-2-ynylamino>benzoate 
• 107174-54-9 4-prop-2-ynylamino-benzoic acid 
• 161878-85-9 (S)-2-((S)-4-tert-Butoxycarbonyl-4-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyrylamino)-hexanedioic acid di-tert-butyl ester 

Relevant academic research and scientific papers

SYNTHESIS OF CYCLOPENTAQUINAZOLINES

A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N-{N-{4- [N-((6S)-2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin

Quinazoline thymidylate synthase inhibitors

The invention relates to quinazoline derivatives or pharceutically-acceptable salts thereof, which possess anti-tumor activity; to processes for their manufacture; and to pharmaceutical compositions containing them. The invention provides a quinazoline of the formula: STR1 wherein R1 is (1-4C)alkyl; the quinazoline ring may optionally bear one or two further substituents selected from halogeno, (1-4C)alkyl and (1-4C)alkoxy; R2 is hydrogen or (1-4C)alkyl; R3 includes hydrogen and (1-4C)alkyl; and Ar is optionally substituted phenylene or heterocyclene; or a pharmaceutically-acceptable salt or ester thereof.

Quinazoline antifolate thymidylate synthase inhibitors: Replacement of glutamic acid in the C2-methyl series

The synthesis of a series of analogues of the potent thymidylate synthase (TS) inhibitor N-[4[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N- prop-2-ynylamino]benzoyl]-L-glutamic acid (ICI 198583, 1) is described in which the glutamic acid residu

Syntheses and Thymidylate Synthase Inhibitory Activity of the Poly-γ-glutamyl Conjugates of N--2-thenoyl>-L-glutamic Acid (ICI D1694) and Other Quinazoline Antifolates

Thirteen poly-γ-glutamates derived from several novel antifolates have been synthesized by a convergent route.The syntheses of poly-γ-glutamyl conjugates of N--2-thenoyl>-L-glutamic aci