N-(1-(1-acryloylpiperidin-3-yl)-1H-benzo[d]imidazol-2-yl)-4-chlorobenzamide

Base Information

Chemical Name:N-(1-(1-acryloylpiperidin-3-yl)-1H-benzo[d]imidazol-2-yl)-4-chlorobenzamide
CAS No.:1575817-36-5
Molecular Formula:C₂₂H₂₁ClN₄O₂
Molecular Weight:408.887
Hs Code.:

Synonyms:N-(1-(1-acryloylpiperidin-3-yl)-1H-benzo[d]imidazol-2-yl)-4-chlorobenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(1-(1-acryloylpiperidin-3-yl)-1H-benzo[d]imidazol-2-yl)-4-chlorobenzamide

Chemical Property:

Purity/Quality:

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Technology Process of N-(1-(1-acryloylpiperidin-3-yl)-1H-benzo[d]imidazol-2-yl)-4-chlorobenzamide

There total 7 articles about N-(1-(1-acryloylpiperidin-3-yl)-1H-benzo[d]imidazol-2-yl)-4-chlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1575819-19-0
4-chloro-N-(1-(piperidin-3-yl)-1H-benzo[d]imidazol-2-yl)benzamide hydrochloride

: 814-68-6,25189-84-8
acryloyl chloride

: 1575817-36-5
N-(1-(1-acryloylpiperidin-3-yl)-1H-benzo[d]imidazol-2-yl)-4-chlorobenzamide

Guidance literature:: In tetrahydrofuran; toluene; at -30 ℃; for 0.333333h; Inert atmosphere;

Reference yield:

: 1089274-75-8
tert-butyl 3-(2-aminophenyl-amino)piperidine-1-carboxylate

: 1575817-36-5
N-(1-(1-acryloylpiperidin-3-yl)-1H-benzo[d]imidazol-2-yl)-4-chlorobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 2 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane / 16 h / 10 - 20 °C / Inert atmosphere

4: toluene; tetrahydrofuran / 0.33 h / -30 °C / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;

Reference yield:

: tert-butyl 3-(2-nitrophenylamino)-piperidine-1-carboxylate

: 1575817-36-5
N-(1-(1-acryloylpiperidin-3-yl)-1H-benzo[d]imidazol-2-yl)-4-chlorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C / Inert atmosphere

2: ethanol / 2 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane / 16 h / 10 - 20 °C / Inert atmosphere

5: toluene; tetrahydrofuran / 0.33 h / -30 °C / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; toluene;