(S)-2--3-(3-tert-butyl-5-oxo-2H-isoxazol-4-yl)propionic acid

Base Information

• Chemical Name: (S)-2--3-(3-tert-butyl-5-oxo-2H-isoxazol-4-yl)propionic acid
• CAS No.: 163685-22-1
• Molecular Formula: C₂₉H₂₈N₂O₄
• Molecular Weight: 468.552
• Mol file: 163685-22-1.mol

Synonyms:(S)-2--3-(3-tert-butyl-5-oxo-2H-isoxazol-4-yl)propionic acid

Chemical Property of (S)-2--3-(3-tert-butyl-5-oxo-2H-isoxazol-4-yl)propionic acid

Chemical Property:

Purity/Quality:

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Technology Process of (S)-2--3-(3-tert-butyl-5-oxo-2H-isoxazol-4-yl)propionic acid

There total 1 articles about (S)-2--3-(3-tert-butyl-5-oxo-2H-isoxazol-4-yl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(2S,4RS)-6,6-dimethyl-5-oxo-4-<(methyloxy)carbonyl>-2-heptanoic acid (185142-04-5) → (S)-2--3-(3-tert-butyl-5-oxo-2H-isoxazol-4-yl)propionic acid (163685-22-1)

Guidance literature:

With sodium hydroxide; hydroxylamine hydrochloride; In methanol; for 1.66667h;

DOI:10.1021/jo00115a039

Reference yield: 52.0%

(S)-2--3-(3-tert-butyl-5-oxo-2H-isoxazol-4-yl)propionic acid (163685-22-1) + methyl iodide (74-88-4) → (2S)-Methyl 2--3-(2-methyl-3-tert-butyl-5-oxo-2H-isoxazol-4-yl)propionate + (2S,4S)-Methyl 2--3-(3-tert-butyl-4-methyl-5-oxo-4H-isoxazol-4-yl)propionate

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 36h;

DOI:10.1021/jo00115a039

upstream raw materials:

(2S,4RS)-6,6-dimethyl-5-oxo-4-<(methyloxy)carbonyl>-2-heptanoic acid