3-(4-fluorophenyl)-3-methylindoline

Base Information

• Chemical Name: 3-(4-fluorophenyl)-3-methylindoline
• CAS No.: 1151856-21-1
• Molecular Formula: C₁₅H₁₄FN
• Molecular Weight: 227.281
• Mol file: 1151856-21-1.mol

Synonyms:3-(4-fluorophenyl)-3-methylindoline

Chemical Property of 3-(4-fluorophenyl)-3-methylindoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-fluorophenyl)-3-methylindoline

There total 4 articles about 3-(4-fluorophenyl)-3-methylindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-Methylindole (83-34-1) + 4-fluorophenyl-1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate (41605-55-4) → 3-(4-fluorophenyl)-3-methylindoline (1151856-21-1)

Guidance literature:

3-Methylindole; 4-fluorophenyl-1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate; With Cy-DHTP*HBF₄; palladium diacetate; lithium tert-butoxide; In toluene; at 110 ℃; for 12h; Sealed tube; Inert atmosphere;

With sodium cyanoborohydride; In methanol; dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.0c01494

Reference yield: 35.0%

3-Methylindole (83-34-1) + bis(4-fluorophenyl)iodonium tetrafluoroborate → 3-(4-fluorophenyl)-3-methylindoline (1151856-21-1)

Guidance literature:

3-Methylindole; bis(4-fluorophenyl)iodonium tetrafluoroborate; With N,N,N′,N′-tetramethyl-N″-tert-butylguanidine; In dichloromethane; toluene; Inert atmosphere;

With sodium cyanoborohydride; In methanol; dichloromethane; for 0.5h;

With silica gel; In methanol; dichloromethane; for 0.5h;

DOI:10.1016/j.tet.2008.09.028

Reference yield: 23.0%

3-Methylindole (83-34-1) + 4-fluorophenyl trifluoromethanesulfonate (132993-23-8) → 3-(4-fluorophenyl)-3-methylindoline (1151856-21-1)

Guidance literature:

3-Methylindole; 4-fluorophenyl trifluoromethanesulfonate; 2; With Cy-DHTP*HBF₄; palladium diacetate; lithium tert-butoxide; In toluene; at 110 ℃; for 20h; Sealed tube; Inert atmosphere;

With sodium cyanoborohydride; In methanol; dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.0c01494

upstream raw materials:

3-Methylindole

4-fluorophenyl-1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

1-Chloro-4-fluorobenzene

4-fluorophenyl trifluoromethanesulfonate