132993-23-8

Basic information

• Product Name: 4-fluorophenyl trifluoromethanesulfonate
• Synonyms: 4-fluorophenyl trifluoromethanesulfonate
• CAS NO: 132993-23-8
• Molecular Weight: 244.167
• Mol File: 132993-23-8.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: 4-fluorophenyl trifluoromethanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-fluorophenyl trifluoromethanesulfonate(132993-23-8)
• EPA Substance Registry System: 4-fluorophenyl trifluoromethanesulfonate(132993-23-8)

Safety Data

• Hazardous Substances Data: 132993-23-8(Hazardous Substances Data)

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 135-19-3 β-naphthol 
• 371-41-5 4-Fluorophenol 
• 1493-13-6 trifluorormethanesulfonic acid 

Downstream Products

• 324-74-3 4-fluoro-biphenyl 
• 330-83-6 N-(4-fluorophenyl)aniline 
• 18437-73-5 diphenyl-p-fluorobenzene-phosphine oxide 
• 49834-29-9 N-(tert-butyl)-4-fluorobenzamide 
• 459-57-4 4-fluorobenzaldehyde 
• 1151856-21-1 3-(4-fluorophenyl)-3-methylindoline 
• 38695-26-0 1-(4-fluorobenzyl)-4-methoxybenzene 
• 45941-97-7 2-(4-fluorophenyl)-2-propen-1-ol 
• 72358-74-8 4-fluoro-o-phenyl phenyl(phenyl)phosphinate 

Relevant articles and documents

Benzothiazol-2-yl(difluoro)methanesulfonic acid: Synthesis and reactions

The condensation of o-aminothiophenol with sulfodifluoroacetic acid led to the formation of benzothiazol-2-yl(difluoro)methanesulfonic acid whose aryldiazonium salts were converted by pyrolysis into aryl benzothiazol-2- yl(difluoro)methanesulfonates. Nauka/Interperiodica 2006.

Dynamic Kinetic Cross-Electrophile Arylation of Benzyl Alcohols by Nickel Catalysis

Catalytic transformation of alcohols via metal-catalyzed cross-coupling reactions is very important, but it typically relies on a multistep procedure. We here report a dynamic kinetic cross-coupling approach for the direct functionalization of alcohols. The feasibility of this strategy is demonstrated by a nickel-catalyzed cross-electrophile arylation reaction of benzyl alcohols with (hetero)aryl electrophiles. The reaction proceeds with a broad substrate scope of both coupling partners. The electron-rich, electron-poor, and ortho-/meta-/para-substituted (hetero)aryl electrophiles (e.g., Ar-OTf, Ar-I, Ar-Br, and inert Ar-Cl) all coupled well. Most of the functionalities, including aldehyde, ketone, amide, ester, nitrile, sulfone, furan, thiophene, benzothiophene, pyridine, quinolone, Ar-SiMe3, Ar-Bpin, and Ar-SnBu3, were tolerated. The dynamic nature of this method enables the direct arylation of benzylic alcohol in the presence of various nucleophilic groups, including nonactivated primary/secondary/tertiary alcohols, phenols, and free indoles. It thus offers a robust alternative to existing methods for the precise construction of diarylmethanes. The synthetic utility of the method was demonstrated by a concise synthesis of biologically active molecules and by its application to peptide modification and conjugation. Preliminary mechanistic studies revealed that the reaction of in situ formed benzyl oxalates with nickel, possibly via a radical process, is an initial step in the reaction with aryl electrophiles.

Palladium-Catalyzed Cyclobutanation of Aryl Sulfonates through both C-O and C-H Cleavage

A palladium-catalyzed cyclobutanation of aryl sulfonates with strained alkenes has been developed. The methodology is featured to achieve the cleavage of both C-O and C-H bonds of phenol derivatives in one pot. Under the reaction conditions, in addition t