[5-(2-trifluoromethyl-phenyl)-isoxazol-4-yl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[5-(2-trifluoromethyl-phenyl)-isoxazol-4-yl]-carbamic acid tert-butyl ester
CAS No.:1224944-83-5
Molecular Formula:C₁₅H₁₅F₃N₂O₃
Molecular Weight:328.291
Hs Code.:

Synonyms:[5-(2-trifluoromethyl-phenyl)-isoxazol-4-yl]-carbamic acid tert-butyl ester

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Chemical Property of [5-(2-trifluoromethyl-phenyl)-isoxazol-4-yl]-carbamic acid tert-butyl ester

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Technology Process of [5-(2-trifluoromethyl-phenyl)-isoxazol-4-yl]-carbamic acid tert-butyl ester

There total 5 articles about [5-(2-trifluoromethyl-phenyl)-isoxazol-4-yl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₁H₅ClF₃NO₂

: 75-65-0
tert-butyl alcohol

: 1224944-83-5
[5-(2-trifluoromethyl-phenyl)-isoxazol-4-yl]-carbamic acid tert-butyl ester

Guidance literature:: C₁₁H₅ClF₃NO₂; With sodium azide; In acetone; for 1h; Inert atmosphere; Cooling with ice;

tert-butyl alcohol; for 16h; Reflux; Inert atmosphere;

Reference yield:

: 76344-91-7
5-[2-(trifluoromethyl)phenyl]isoxazole-4-carboxylic acid ethyl ester

: 1224944-83-5
[5-(2-trifluoromethyl-phenyl)-isoxazol-4-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; acetic acid / water / 5.5 h / Reflux; Inert atmosphere

2.1: thionyl chloride / 3 h / Inert atmosphere; Reflux

3.1: sodium azide / acetone / 1 h / Inert atmosphere; Cooling with ice

3.2: 16 h / Reflux; Inert atmosphere

With hydrogenchloride; thionyl chloride; sodium azide; acetic acid; In water; acetone;

Reference yield:

: 1003561-80-5
5-[2-(trifluoromethyl)phenyl]isoxazole-4-carboxylic acid

: 1224944-83-5
[5-(2-trifluoromethyl-phenyl)-isoxazol-4-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 3 h / Inert atmosphere; Reflux

2.1: sodium azide / acetone / 1 h / Inert atmosphere; Cooling with ice

2.2: 16 h / Reflux; Inert atmosphere

With thionyl chloride; sodium azide; In acetone;