4-((6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)methylamino)-1-(hydroxymethyl)bicyclo[2.2.2]octan-2-ol

Base Information

Chemical Name:4-((6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)methylamino)-1-(hydroxymethyl)bicyclo[2.2.2]octan-2-ol
CAS No.:1544658-13-0
Molecular Formula:C₃₀H₄₃NO₃
Molecular Weight:465.676
Hs Code.:

Synonyms:4-((6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)methylamino)-1-(hydroxymethyl)bicyclo[2.2.2]octan-2-ol

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Chemical Property of 4-((6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)methylamino)-1-(hydroxymethyl)bicyclo[2.2.2]octan-2-ol

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Technology Process of 4-((6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)methylamino)-1-(hydroxymethyl)bicyclo[2.2.2]octan-2-ol

There total 7 articles about 4-((6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)methylamino)-1-(hydroxymethyl)bicyclo[2.2.2]octan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1266115-60-9
6-(trans-4-tert-butylcyclohexyloxy)-2-naphthaldehyde

: 1544662-64-7
4-amino-1-(hydroxymethyl)bicyclo[2.2.2]octan-2-ol

: 1544658-13-0
4-((6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)methylamino)-1-(hydroxymethyl)bicyclo[2.2.2]octan-2-ol

Guidance literature:: 6-(trans-4-tert-butylcyclohexyloxy)-2-naphthaldehyde; 4-amino-1-(hydroxymethyl)bicyclo[2.2.2]octan-2-ol; With acetic acid; In dichloromethane; for 0.5h; Reflux;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 72653-21-5
ethyl 1-acetyl-4-oxocyclohexane-1-carboxylate

: 1544658-13-0
4-((6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)methylamino)-1-(hydroxymethyl)bicyclo[2.2.2]octan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 24 h / Dean-Stark; Reflux

2.1: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C

3.1: sodium tetrahydroborate / ethanol / 0.5 h / 0 °C

4.1: acetic acid / dichloromethane / 0.5 h / Reflux

4.2: 16 h / 20 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; acetic acid; In methanol; ethanol; dichloromethane; toluene;

Reference yield:

: 1544662-57-8
ethyl 4-amino-2-oxobicyclo[2.2.2]octane-1-carboxylate

: 1544658-13-0
4-((6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)methylamino)-1-(hydroxymethyl)bicyclo[2.2.2]octan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / ethanol / 0.5 h / 0 °C

2.1: acetic acid / dichloromethane / 0.5 h / Reflux

2.2: 16 h / 20 °C

With sodium tetrahydroborate; acetic acid; In ethanol; dichloromethane;