1-<5-O-trityl-2-(1,2,4-triazol-1-yl)-2-deoxy-β-D-xylofuranosyl>thymine

Base Information

• Chemical Name: 1-<5-O-trityl-2-(1,2,4-triazol-1-yl)-2-deoxy-β-D-xylofuranosyl>thymine
• CAS No.: 124355-33-5
• Molecular Formula: C₃₁H₂₉N₅O₅
• Molecular Weight: 551.602
• Mol file: 124355-33-5.mol

Synonyms:1-<5-O-trityl-2-(1,2,4-triazol-1-yl)-2-deoxy-β-D-xylofuranosyl>thymine

Chemical Property of 1-<5-O-trityl-2-(1,2,4-triazol-1-yl)-2-deoxy-β-D-xylofuranosyl>thymine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<5-O-trityl-2-(1,2,4-triazol-1-yl)-2-deoxy-β-D-xylofuranosyl>thymine

There total 1 articles about 1-<5-O-trityl-2-(1,2,4-triazol-1-yl)-2-deoxy-β-D-xylofuranosyl>thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,4-Triazole (288-88-0) + 1-(2,3-epoxy-5-O-trityl-β-D-lyxo-pentofuranosyl)thymine (115913-84-3) → 1-<5-O-trityl-2-(1,2,4-triazol-1-yl)-2-deoxy-β-D-xylofuranosyl>thymine (124355-33-5) + 1-<5-O-trityl-3-(1,2,4-triazol-1-yl)-3-deoxy-β-D-arabinofuranosyl>thymine (124355-32-4)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1.) DMF, room temp., 15 min, 2.) 100 deg C, 16 h;

DOI:10.1021/jm00164a063

Reference yield: 91.0%

1-<5-O-trityl-2-(1,2,4-triazol-1-yl)-2-deoxy-β-D-xylofuranosyl>thymine (124355-33-5) → 1-<2-(1,2,4-triazol-1-yl)-2-deoxy-β-D-xylofuranosyl>thymine (124355-35-7)

Guidance literature:

With acetic acid; In methanol; at 100 ℃; for 1.5h;

DOI:10.1021/jm00164a063

Reference yield: 44.0%

1-<5-O-trityl-2-(1,2,4-triazol-1-yl)-2-deoxy-β-D-xylofuranosyl>thymine (124355-33-5) + 1,1'-carbonyldiimidazole (530-62-1) → Imidazole-1-carboxylic acid (2R,3R,4R,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-[1,2,4]triazol-1-yl-2-trityloxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:

With pyridine; at 90 ℃; for 3h;

DOI:10.1021/jm00164a063

upstream raw materials:

1,2,4-Triazole

1-(2,3-epoxy-5-O-trityl-β-D-lyxo-pentofuranosyl)thymine

Downstream raw materials:

1-<2-(1,2,4-triazol-1-yl)-2-deoxy-β-D-xylofuranosyl>thymine

1-<5-O-trityl-2-(1,2,4-triazol-1-yl)-2,3-dideoxy-β-D-erythro-pentofuranosyl>thymine