5-bromo-5-(3,5-difluorophenyl)-1-(4-methylsulfanylphenyl)pent-4-en-1-one

Base Information

Chemical Name:5-bromo-5-(3,5-difluorophenyl)-1-(4-methylsulfanylphenyl)pent-4-en-1-one
CAS No.:324529-53-5
Molecular Formula:C₁₈H₁₅BrF₂OS
Molecular Weight:397.283
Hs Code.:

Synonyms:5-bromo-5-(3,5-difluorophenyl)-1-(4-methylsulfanylphenyl)pent-4-en-1-one

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Chemical Property of 5-bromo-5-(3,5-difluorophenyl)-1-(4-methylsulfanylphenyl)pent-4-en-1-one

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Technology Process of 5-bromo-5-(3,5-difluorophenyl)-1-(4-methylsulfanylphenyl)pent-4-en-1-one

There total 4 articles about 5-bromo-5-(3,5-difluorophenyl)-1-(4-methylsulfanylphenyl)pent-4-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 151361-87-4
1-ethynyl-3,5-difluorobenzene

: 21573-80-8
1-(4-methylthiophenyl)propenone

: 324529-53-5
5-bromo-5-(3,5-difluorophenyl)-1-(4-methylsulfanylphenyl)pent-4-en-1-one

Guidance literature:: With stannic bromide; lithium bromide; cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; In acetone; at 60 ℃;
DOI:10.1016/S0040-4039(00)01735-4

Reference yield:

: 13205-48-6,562836-64-0
4-(methylthio)benzoic acid

: 324529-53-5
5-bromo-5-(3,5-difluorophenyl)-1-(4-methylsulfanylphenyl)pent-4-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: (COCl)2 / CH₂Cl₂ / 2 h / 40 °C

2: 348 mg / palladium(II) bis(triphenylphosphine)benzyl chloride / toluene / 4 h / 80 °C

3: 64 percent / [CpRu(CH₃CN)3]PF₆; SnBr₄; LiBr / acetone / 2 h / 60 °C

With oxalyl dichloride; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; stannic bromide; lithium bromide; In dichloromethane; acetone; toluene; 2: Stille coupling;
DOI:10.1021/jo010593b

Reference yield:

: 461-96-1
3,5-difluorobromobenzene

: 324529-53-5
5-bromo-5-(3,5-difluorophenyl)-1-(4-methylsulfanylphenyl)pent-4-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: CuI / (PhCN)2PdCl₂ / methanol

1.2: 68 percent / K₂CO₃ / methanol

2.1: 64 percent / SnBr₄; LiBr / [CpRu(NCCH₃)3]⁽¹⁺⁾*PF₆^(1-) / acetone / 60 °C

With copper(l) iodide; stannic bromide; lithium bromide; bis(benzonitrile)palladium(II) dichloride; cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; In methanol; acetone;
DOI:10.1016/S0040-4039(00)01735-4