[3-Hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate

Base Information

Chemical Name:[3-Hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate
CAS No.:365-07-1
Molecular Formula:C10H15N2O8P
Molecular Weight:322.211
Hs Code.:HOSPHATE PRODUCT IDENTIFICATION
NSC Number:46713
DSSTox Substance ID:DTXSID10861902
Wikidata:Q105024006

Synonyms:Thymidine 5'MP;NSC-46713;thymidine 5'-monophos-phate;SCHEMBL16092807;DTXSID10861902;CHEBI:181566;NSC46713;[3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate;L001240;1-(2-Deoxy-5-O-phosphonopentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione

Suppliers and Price of [3-Hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
TMP disodium salt
A103X
$ 350.00

Sigma-Aldrich
TMP disodium salt
A102X
$ 101.00

Chemenu
((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyldihydrogenphosphate 95%
5g
$ 916.00

Chemenu
((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyldihydrogenphosphate 95%
1g
$ 355.00

Total 35 raw suppliers

Chemical Property of [3-Hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate

Chemical Property:

Appearance/Colour:white crystalline powder
PKA:1.86±0.10(Predicted)
PSA：160.89000
Density:1.654 g/cm³
LogP:-1.39730
Storage Temp.:−20°C
XLogP3:-2.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:322.05660244
Heavy Atom Count:21
Complexity:529

Purity/Quality:: TMP disodium salt ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)O)O

Technology Process of [3-Hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate

There total 95 articles about [3-Hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 365-07-1,15108-71-1,60363-32-8,96744-88-6,132696-16-3,143838-77-1
thymidine 5'-phosphate

Guidance literature:: With tris(p-nitrophenyl)phosphate; at 50 ℃; Erwina herbicola 47/3 cells;
DOI:10.1007/BF00598099

Reference yield:

: C₁₀H₁₃N₂O₅Pol

: 365-07-1,15108-71-1,60363-32-8,96744-88-6,132696-16-3,143838-77-1
thymidine 5'-phosphate

Guidance literature:: C₁₀H₁₃N₂O₅Pol; With 1H-tetrazole; C₆₀H₆₀NO₆P; In acetonitrile; for 0.1h; Succinyl Long Chain Alkylamine Controlled-Pore Glass

With pyridine; water; iodine; In tetrahydrofuran; for 0.5h; Succinyl Long Chain Alkylamine Controlled-Pore Glass

With ammonium hydroxide; In water; at 50 ℃; for 5h; Succinyl Long Chain Alkylamine Controlled-Pore Glass Reagent/catalyst;
DOI:10.1016/j.tetlet.2017.02.034

Reference yield:

NovaSyn^TM Tentagel resin-S-bound [2-(5-O-thymidine)-1,3,2-oxathiaphospholan-4-yl]methanethiol: NovaSyn^TM Tentagel resin-S-bound [2-(5-O-thymidine)-1,3,2-oxathiaphospholan-4-yl]methanethiol

: 365-07-1,15108-71-1,60363-32-8,96744-88-6,132696-16-3,143838-77-1
thymidine 5'-phosphate

Guidance literature:: NovaSyn^TM Tentagel resin-S-bound [2-(5-O-thymidine)-1,3,2-oxathiaphospholan-4-yl]methanethiol; With tert.-butylhydroperoxide; In tetrahydrofuran; decane; at 20 ℃; for 1h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-Hydroxypropionitrile; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1021/ol050385w