(E)-5-{1-[3-(methanesulfonamide)phenyl]propylidene}-1-methyl-5,11-dihydrobenzo[6,7]oxepino[4,3-f]indazole

Base Information

Chemical Name:(E)-5-{1-[3-(methanesulfonamide)phenyl]propylidene}-1-methyl-5,11-dihydrobenzo[6,7]oxepino[4,3-f]indazole
CAS No.:1202526-93-9
Molecular Formula:C₂₆H₂₅N₃O₃S
Molecular Weight:459.569
Hs Code.:

Synonyms:(E)-5-{1-[3-(methanesulfonamide)phenyl]propylidene}-1-methyl-5,11-dihydrobenzo[6,7]oxepino[4,3-f]indazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-5-{1-[3-(methanesulfonamide)phenyl]propylidene}-1-methyl-5,11-dihydrobenzo[6,7]oxepino[4,3-f]indazole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (E)-5-{1-[3-(methanesulfonamide)phenyl]propylidene}-1-methyl-5,11-dihydrobenzo[6,7]oxepino[4,3-f]indazole

There total 13 articles about (E)-5-{1-[3-(methanesulfonamide)phenyl]propylidene}-1-methyl-5,11-dihydrobenzo[6,7]oxepino[4,3-f]indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1086063-64-0
3-(methanesulfonamide)phenylboronic acid

: 1202528-01-5
(E)-5-(1-bromopropylidene)-1-methyl-5,11-dihydrobenzo-[6,7]oxepino[4,3-f]indazole

: 1202526-93-9
(E)-5-{1-[3-(methanesulfonamide)phenyl]propylidene}-1-methyl-5,11-dihydrobenzo[6,7]oxepino[4,3-f]indazole

Guidance literature:: With sodium carbonate; palladium diacetate; triphenylphosphine; In 1,4-dioxane; water; at 70 ℃; for 7h;

Reference yield:

: 2050-44-4
N-(2,5-dimethylphenyl)acetamide

: 1202526-93-9
(E)-5-{1-[3-(methanesulfonamide)phenyl]propylidene}-1-methyl-5,11-dihydrobenzo[6,7]oxepino[4,3-f]indazole

Guidance literature:: Multi-step reaction with 12 steps

1.1: bromine / acetic acid / 3 h / 20 °C

2.1: acetic anhydride; potassium acetate; isopentyl nitrate / 18-crown-6 ether / chloroform / 3 h / 65 °C

3.1: hydrogenchloride / water; methanol / 1 h / 100 °C

3.2: Cooling with ice

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

4.2: 1.5 h / Cooling with ice

5.1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 9 h / 90 °C

6.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide; α,α,α-trifluorotoluene / α,α,α-trifluorotoluene / 0.55 h / 20 - 130 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

8.1: potassium hydroxide; water / ethanol / 5 h / 40 °C

9.1: polyphosphoric acid / 1 h / 90 °C

10.1: n-propyltriphenylphosphonium bromide / tetrahydrofuran / 2 h / -10 - 20 °C

10.2: 12 h / 20 °C

11.1: 4-(dimethylamino)-pyridinium tribromide / acetonitrile / 4 h / 80 °C

12.1: sodium carbonate / triphenylphosphine; palladium diacetate / 1,4-dioxane; water / 7 h / 70 °C

With hydrogenchloride; N-Bromosuccinimide; isopentyl nitrate; 2,2'-azobis(isobutyronitrile); α,α,α-trifluorotoluene; 4-(dimethylamino)-pyridinium tribromide; water; bromine; potassium acetate; n-propyltriphenylphosphonium bromide; acetic anhydride; sodium hydride; sodium carbonate; potassium carbonate; triethylamine; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 18-crown-6 ether; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; chloroform; α,α,α-trifluorotoluene; water; acetic acid; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 95-78-3
2,5-Dimethylaniline

: 1202526-93-9
(E)-5-{1-[3-(methanesulfonamide)phenyl]propylidene}-1-methyl-5,11-dihydrobenzo[6,7]oxepino[4,3-f]indazole

Guidance literature:: Multi-step reaction with 13 steps

1.1: toluene / 1 h / 100 °C

2.1: bromine / acetic acid / 3 h / 20 °C

3.1: acetic anhydride; potassium acetate; isopentyl nitrate / 18-crown-6 ether / chloroform / 3 h / 65 °C

4.1: hydrogenchloride / water; methanol / 1 h / 100 °C

4.2: Cooling with ice

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

5.2: 1.5 h / Cooling with ice

6.1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 9 h / 90 °C

7.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide; α,α,α-trifluorotoluene / α,α,α-trifluorotoluene / 0.55 h / 20 - 130 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

9.1: potassium hydroxide; water / ethanol / 5 h / 40 °C

10.1: polyphosphoric acid / 1 h / 90 °C

11.1: n-propyltriphenylphosphonium bromide / tetrahydrofuran / 2 h / -10 - 20 °C

11.2: 12 h / 20 °C

12.1: 4-(dimethylamino)-pyridinium tribromide / acetonitrile / 4 h / 80 °C

13.1: sodium carbonate / triphenylphosphine; palladium diacetate / 1,4-dioxane; water / 7 h / 70 °C

With hydrogenchloride; N-Bromosuccinimide; isopentyl nitrate; 2,2'-azobis(isobutyronitrile); α,α,α-trifluorotoluene; 4-(dimethylamino)-pyridinium tribromide; water; bromine; potassium acetate; n-propyltriphenylphosphonium bromide; acetic anhydride; sodium hydride; sodium carbonate; potassium carbonate; triethylamine; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 18-crown-6 ether; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; chloroform; α,α,α-trifluorotoluene; water; acetic acid; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;