2050-44-4

Usage

Uses

Used in Pharmaceutical Industry:
2',4'-DIMETHYLACETANILIDE is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new medications and therapeutic agents.
Used in Dye and Pigment Production:
In the dye and pigment industry, 2',4'-DIMETHYLACETANILIDE is utilized in the production of dyes and pigments, providing colorants for a range of applications, including textiles, plastics, and printing inks.
Used in Organic Chemistry Research:
2',4'-DIMETHYLACETANILIDE serves as a reagent in organic chemistry research, facilitating the study of chemical reactions and the development of novel organic compounds and materials.

InChI:InChI=1/C10H13NO/c1-7-4-5-8(2)10(6-7)11-9(3)12/h4-6H,1-3H3,(H,11,12)

Upstream product

• 95-78-3 2,5-Dimethylaniline 
• 64-19-7 acetic acid 
• 537-92-8 3-Methylacetanilide 
• 74-88-4 methyl iodide 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 5692-34-2 2,5-dimethylbenzamide 
• 75-36-5 acetyl chloride 
• 123-54-6 acetylacetone 
• 17075-25-1 1,4-dimethyl-2-nitrosobenzene 
• 431-03-8 dimethylglyoxal 
• 108-44-1 1-amino-3-methylbenzene 
• 112359-25-8 5-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate 
• 106-42-3 para-xylene 
• 75-05-8 acetonitrile 

Downstream Products

• 194735-89-2 acetic acid-(2,4-dichloro-3,6-dimethyl-anilide) 
• 873979-22-7 acetic acid-(2,4,5-trichloro-3,6-dimethyl-anilide) 
• 13711-31-4 N-(4-bromo-2,5-dimethyl-phenyl)acetamide 
• 387819-85-4 N-(4-bromophenyl)-N-(2,5-dimethylphenyl)amine 
• 519-23-3 ellipticine 
• 23410-20-0 2,5-dimethyl-4-aminoacetanilide 
• 1074-24-4 2,5-dibromo-p-xylene 
• 30273-40-6 4-bromo-2,5-dimethylaniline 
• 6393-01-7 2,5-Dimethyl-1,4-phenylenediamine 
• 6311-52-0 3,6-dimethyl-2,4-dinitro-aniline 
• 227467-72-3 4'-(2-bromoacetyl)-2',5'-dimethylacetanilide 
• 1281763-75-4 4'-methoxy-2',5'-dimethylacetanilide 
• 3096-93-3 1-Acetoxy-4-acetylamino-2,5-dimethylbenzene 
• 15540-81-5 1-bromo-2,5-dimethyl-4-nitrobenzene 

Relevant academic research and scientific papers

Synthesis of indenoquinolinone through aryne-mediated Pd(II)-catalysed remote C–H activation

Abstract: [Figure not available: see fulltext.]Indenoquinolinones have been synthesized from 2-haloquinoline-3-carbaldehyde through Pd-mediated simultaneous C–H (aldehyde) and C–X bond activation. DFT studies were performed to investigate the mechanistic pathway, and in situ UV–Vis studies indicate the presence of Pd(II) intermediate species. Aryne ligated Pd complex is actual intermediate in these reactions. Ligation of reactive aryne to Pd reduces probability of side reactions. Graphic abstract: [Figure not available: see fulltext.]

Catalyst-free generation of acyl radicals induced by visible light in water to construct C-N bonds

We describe herein a catalyst-free and redox-neutral photochemical strategy for the direct generation of acyl radicals from α-diketones, and its selective conversion of nitrosoarenes to hydroxyamides or amides with AcOH or NaCl as an additive. The reaction was carried out under mild conditions in water with purple LEDs as the light source. A broad scope of substrates was demonstrated. Mechanistic experiments indicate that α-diketones cleave to give acyl radicals, with hydroxyamides being further reduced to amides.

NOVEL AGROCHEMICAL COMPOSITION COMPRISING 4-SUBSTITUTED PHENYLAMIDINE COMPOUNDS

The present invention discloses a novel agrochemical composition comprising (1) at lease one compound of formula (I) wherein, R1, R2, R3, R4, R5, R6, R7 and m are as defined in t

Synthesis of diverse libraries of carboxamides via chemoselective N-acylation of amines by carboxylic acids employing Br?nsted acidic IL [BMIM(SO3H)][OTf]

Chemoselective N-acylation of amines with carboxylic acids as acyl electrophiles and Br?nsted acidic IL [BMIM(SO3H)][OTf] as promoter is reported under both thermal and microwave irradiation to produce libraries of carboxamides in good to excellent yields after a simple workup. The protocol is compatible with structurally diverse 1° and 2° amines and works in the presence of sensitive functional groups such as thiols and phenols. The potential for recycling and reuse of the IL is also demonstrated.

Acylation of Phenols, Alcohols, Thiols, Amines and Aldehydes Using Sulfonic Acid Functionalized Hyper-Cross-Linked Poly(2-naphthol) as a Solid Acid Catalyst

Abstract: The hyper-cross-linked porous poly(2-naphthol) fabricated by the Friedel–Crafts alkylation of 2-naphthol has been functionalized with sulfonic acid to obtain a solid acid catalyst. The catalyst is applied for the protection of phenol, alcohols, thiols, amines and aldehydes with acetic anhydride at room temperature. The catalytic protection using the new solid acid is featured by achieving high yield at neat condition, needing no aqueous work-up and/or chromatographic separation, and showing excellent recycling efficiency, suggesting the potential of this sulfonated porous polymers as a new protection protocol in a wide range of sustainable chemical reactions. Graphical Abstract: [Figure not available: see fulltext.].

4,5,6-TRI-SUBSTITUTED INDAZOLES DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN MEDICINES

Provided are 4,5,6-tri-substituted indazoles derivatives, a preparation method therefor, and a use thereof in medicines. Specifically, provided are compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates, or prodrugs thereof

Sulfonium Salts as Alkylating Agents for Palladium-Catalyzed Direct Ortho Alkylation of Anilides and Aromatic Ureas

A novel method for the ortho alkylation of acetanilide and aromatic urea derivatives via C-H activation was developed. Alkyl dibenzothiophenium salts are considered to be new reagents for the palladium-catalyzed C-H activation reaction, which enables the transfer of methyl and other alkyl groups from the sulfonium salt to the aniline derivatives under mild catalytic conditions.

NOVEL PHENYLAMINE COMPOUNDS

The present invention relates to 4-substituted phenylamidine derivatives of the general formula (I), wherein R5-R6, ArA4, D, G, B, Q and an integer m have the meanings as defined in the description. The invention further relates to methods for their preparation and use of said compounds for controlling undesired phytopathogenic microorganisms, and agents for said purpose, comprising said phenylamine derivatives. This invention further relates to a method for controlling undesired phytopathogenic microorganisms by application of said 4-substituted phenylamidine derivatives of general formula (I) to such undesired microorganisms and/or to their habitat, according to the invention.

Sulfated choline ionic liquid-catalyzed acetamide synthesis by grindstone method

Sulfated choline ionic liquid (SCIL) has been found to be an efficient solid acid IL catalyst for the protection of amine groups with acetic anhydride under solvent-free grindstone conditions. The attractive features of this new catalytic methodology include its sustainability, facile work-up procedure, economic viability, and biodegradability. The SCIL catalyst was characterized using infrared spectroscopy, wide-angle X-ray scattering analysis, and scanning electron microscopy with energy dispersive X-ray spectroscopy. The catalyst could be reused six times without significant loss in activity. Furthermore, no chromatographic separations were needed to obtain the desired products.

Synthesis and Herbicidal Activity of Triketone-Quinoline Hybrids as Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is one of the most important targets for herbicide discovery. In the search for new HPPD inhibitors with novel scaffolds, triketone-quinoline hybrids were designed and subsequently optimized on the basis of the structure-activity relationship (SAR) studies. Most of the synthesized compounds displayed potent inhibition of Arabidopsis thaliana HPPD (AtHPPD), and some of them exhibited broad-spectrum and promising herbicidal activity at the rate of 150 g ai/ha by postemergence application. Most promisingly, compound III-l, 3-hydroxy-2-(2-methoxy-7-(methylthio)quinoline-3-carbonyl)cyclohex-2-enone (Ki = 0.009 ～M, AtHPPD), had broader spectrum of weed control than mesotrione. Furthermore, compound III-l was much safer to maize at the rate of 150 g ai/ha than mesotrione, demonstrating its great potential as herbicide for weed control in maize fields. Therefore, triketone-quinoline hybrids may serve as new lead structures for novel herbicide discovery.