N^δ-(tert-butyloxycarbonyl)-N^α-(5-chloro-5,8-dideazaisopteroyl)-L-ornithine

Base Information

Chemical Name:N^δ-(tert-butyloxycarbonyl)-N^α-(5-chloro-5,8-dideazaisopteroyl)-L-ornithine
CAS No.:143745-33-9
Molecular Formula:C₂₆H₃₁ClN₆O₆
Molecular Weight:559.022
Hs Code.:

N<sup>δ</sup>-(tert-butyloxycarbonyl)-N<sup>α</sup>-(5-chloro-5,8-dideazaisopteroyl)-L-ornithine

Synonyms:N^δ-(tert-butyloxycarbonyl)-N^α-(5-chloro-5,8-dideazaisopteroyl)-L-ornithine

Suppliers and Price of N^δ-(tert-butyloxycarbonyl)-N^α-(5-chloro-5,8-dideazaisopteroyl)-L-ornithine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N^δ-(tert-butyloxycarbonyl)-N^α-(5-chloro-5,8-dideazaisopteroyl)-L-ornithine

Chemical Property:

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Technology Process of N^δ-(tert-butyloxycarbonyl)-N^α-(5-chloro-5,8-dideazaisopteroyl)-L-ornithine

There total 8 articles about N^δ-(tert-butyloxycarbonyl)-N^α-(5-chloro-5,8-dideazaisopteroyl)-L-ornithine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 143745-33-9
N^δ-(tert-butyloxycarbonyl)-N^α-(5-chloro-5,8-dideazaisopteroyl)-L-ornithine

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / CaCO₃ / N,N-dimethyl-acetamide / 24 h / 60 °C

2: 34 percent / aq. NaOH / methanol / 18 h / 55 °C

3: 23 h / Ambient temperature

4: Et₃N / dimethylformamide / 1 h / 0 °C

5: Et₃N / dimethylformamide / 14 h / 0 - 20 °C

6: 10percent aq. NH₄OH / 3 h / Ambient temperature

With ammonium hydroxide; sodium hydroxide; triethylamine; calcium carbonate; In methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00100a013

Reference yield:

: 143745-30-6
5-chloro-2,6-diamino-3,4-dihydro-4-oxoquinazoline

: 143745-33-9
N^δ-(tert-butyloxycarbonyl)-N^α-(5-chloro-5,8-dideazaisopteroyl)-L-ornithine

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / CaCO₃ / N,N-dimethyl-acetamide / 24 h / 60 °C

2: 34 percent / aq. NaOH / methanol / 18 h / 55 °C

3: 23 h / Ambient temperature

4: Et₃N / dimethylformamide / 1 h / 0 °C

5: Et₃N / dimethylformamide / 14 h / 0 - 20 °C

6: 10percent aq. NH₄OH / 3 h / Ambient temperature

With ammonium hydroxide; sodium hydroxide; triethylamine; calcium carbonate; In methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00100a013

Reference yield:

: 143745-32-8
5-chloro-5,8-dideazaisopteroic acid

: 143745-33-9
N^δ-(tert-butyloxycarbonyl)-N^α-(5-chloro-5,8-dideazaisopteroyl)-L-ornithine

Guidance literature:: Multi-step reaction with 4 steps

1: 23 h / Ambient temperature

2: Et₃N / dimethylformamide / 1 h / 0 °C

3: Et₃N / dimethylformamide / 14 h / 0 - 20 °C

4: 10percent aq. NH₄OH / 3 h / Ambient temperature

With ammonium hydroxide; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00100a013