(4S,5R)-(-)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid

Base Information

• Chemical Name: (4S,5R)-(-)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid
• CAS No.: 56151-99-6
• Molecular Formula: C₁₉H₂₇NO₅
• Molecular Weight: 349.427
• Mol file: 56151-99-6.mol

Synonyms:(4S,5R)-(-)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid

Chemical Property of (4S,5R)-(-)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,5R)-(-)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid

There total 39 articles about (4S,5R)-(-)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(4S,5R)-(-)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester (56151-96-3) → (4S,5R)-(-)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid (56151-99-6)

Guidance literature:

With sodium hydroxide; In ethanol; for 24h; Ambient temperature;

DOI:10.1016/S0040-4020(01)83119-7

Reference yield: 71.0%

(4S,5R)-(-)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid (56151-99-6) → (5R)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid (56151-99-6,56193-97-6,71358-37-7,74036-02-5,95423-78-2)

Guidance literature:

With hydrogenchloride; for 20h; Heating;

DOI:10.1016/S0040-4020(01)83119-7

Reference yield:

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → (+/-)-trans-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid (56151-99-6,56193-97-6,71358-37-7,74036-02-5,95423-78-2)

Guidance literature:

With ethanol; nickel; at 110 ℃; under 80905.8 Torr; Hydrogenation_.Erwaermen des Reaktionsprodukts mit wss.-aethanol. KOH;

DOI:10.1021/ja01532a027

upstream raw materials:

(+/-)-[5t-ethyl-1-(3,4-dimethoxy-phenethyl)-2-oxo-[4r]piperidyl]-malonic acid

3,4-dimethoxyphenethyl bromide

trans-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

1-(3,4-dimethoxyphenethyl)-5-ethyl-5,6-dihydro-2(1H)-pyridinone

Downstream raw materials:

cis-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid

(+/-)-trans-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid

(5R)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid

(5R)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester