methyl N-{[1-(N'-benzyloxycarbonylamino)-3-methylbutyl]-methoxyphosphinyl}-(L)leucinate

Base Information

Chemical Name:methyl N-{[1-(N'-benzyloxycarbonylamino)-3-methylbutyl]-methoxyphosphinyl}-(L)leucinate
CAS No.:561007-48-5
Molecular Formula:C₂₁H₃₅N₂O₆P
Molecular Weight:442.492
Hs Code.:

Synonyms:methyl N-{[1-(N'-benzyloxycarbonylamino)-3-methylbutyl]-methoxyphosphinyl}-(L)leucinate

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Chemical Property of methyl N-{[1-(N'-benzyloxycarbonylamino)-3-methylbutyl]-methoxyphosphinyl}-(L)leucinate

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Technology Process of methyl N-{[1-(N'-benzyloxycarbonylamino)-3-methylbutyl]-methoxyphosphinyl}-(L)leucinate

There total 7 articles about methyl N-{[1-(N'-benzyloxycarbonylamino)-3-methylbutyl]-methoxyphosphinyl}-(L)leucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 90763-54-5
methyl <1--3-methylbutyl>phosphonate

: 561007-48-5
methyl N-{[1-(N'-benzyloxycarbonylamino)-3-methylbutyl]-methoxyphosphinyl}-(L)leucinate

Guidance literature:: methyl <1--3-methylbutyl>phosphonate; With thionyl chloride; In chloroform; Heating;

methyl (L)-leucinate hydrochloride; With triethylamine; In chloroform; at 20 ℃;
DOI:10.1002/ejoc.200300469

Reference yield:

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 90763-55-6
C₁₄H₂₁ClNO₄P

: 561007-48-5
methyl N-{[1-(N'-benzyloxycarbonylamino)-3-methylbutyl]-methoxyphosphinyl}-(L)leucinate

Guidance literature:: With triethylamine; In chloroform; at 20 ℃;
DOI:10.1021/jm030795v

Reference yield:

: 621-84-1
O-benzyl carbamate

: 561007-48-5
methyl N-{[1-(N'-benzyloxycarbonylamino)-3-methylbutyl]-methoxyphosphinyl}-(L)leucinate

Guidance literature:: Multi-step reaction with 5 steps

1: 38 percent / AcOH

2: 91 percent / KF; 18-crown-6 ether

3: 84 percent / aq. NaOH / methanol

4: SOCl₂ / CHCl₃ / 2 h / Heating

5: NEt₃ / CHCl₃ / 20 °C

With potassium fluoride; sodium hydroxide; thionyl chloride; 18-crown-6 ether; acetic acid; triethylamine; In methanol; chloroform;
DOI:10.1021/jm030795v