90763-55-6

Upstream product

• 590-86-3 isovaleraldehyde 
• 90763-54-5 methyl <1--3-methylbutyl>phosphonate 
• 501-53-1 benzyl chloroformate 
• 128948-79-8 (R)-benzyl N-[1-(dimethoxyphosphoryl)-3-methylbutyl]carbamate 
• 88081-77-0 L-Leucine phosphonate 
• 128948-77-6 <(1R)-1-amino>-3-methylbutyl>phosphonic acid 
• 128948-78-7 methyl hydrogen ((1R)-1-{N-[(phenylmethoxy)carbonyl]amino}-3-methylbutyl)phosphonate 
• 82629-28-5 dimethyl {1-[(benzyloxycarbonyl)amino]-3-methylbutyl}phosphonate 
• 90763-52-3 diphenyl <1--3-methylbutyl>phosphonate 
• 621-84-1 O-benzyl carbamate 

Downstream Products

• 208046-11-1 (S)-2-[((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-methoxy-phosphinoyloxy]-3-phenyl-propionic acid methyl ester 
• 90763-58-9 [((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-methoxy-phosphinoyl]-acetic acid tert-butyl ester 
• 128901-61-1 [((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-methoxy-phosphinoyl]-acetic acid ethyl ester 
• 128901-57-5 Cbz-Leu^P-(O)Phe-Ala-Ala dimethyl ester 
• 207985-90-8 (S)-2-[((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-methoxy-phosphinoyloxy]-3-[3-(tert-butoxycarbonylamino-methyl)-phenyl]-propionic acid methyl ester 
• 207985-94-2 (S)-N-((R)-1-{[(S)-2-(3-Aminomethyl-phenyl)-1-methoxycarbonyl-ethoxy]-methoxy-phosphoryl}-3-methyl-butyl)-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid 
• 207985-91-9 (S)-3-Benzyloxycarbonylamino-N-[(R)-1-({(S)-2-[3-(tert-butoxycarbonylamino-methyl)-phenyl]-1-methoxycarbonyl-ethoxy}-methoxy-phosphoryl)-3-methyl-butyl]-succinamic acid tert-butyl ester 
• 207985-93-1 (S)-N-[(R)-1-({(S)-2-[3-(tert-Butoxycarbonylamino-methyl)-phenyl]-1-methoxycarbonyl-ethoxy}-methoxy-phosphoryl)-3-methyl-butyl]-3-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-succinamic acid tert-butyl ester 
• 207985-92-0 (S)-3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-N-[(R)-1-({(S)-2-[3-(tert-butoxycarbonylamino-methyl)-phenyl]-1-methoxycarbonyl-ethoxy}-methoxy-phosphoryl)-3-methyl-butyl]-succinamic acid tert-butyl ester 
• 109638-89-3 (S)-2-[(1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyloxy]-4-methyl-pentanoic acid 
• 144599-66-6 [(1-Benzyloxycarbonylamino-3-methyl-butyl)-methoxy-phosphinoyl]-acetic acid tert-butyl ester 
• 90763-64-7 [(1-Benzyloxycarbonylamino-3-methyl-butyl)-methoxy-phosphinoyl]-acetic acid 
• 561007-48-5 methyl N-{[1-(N'-benzyloxycarbonylamino)-3-methylbutyl]-methoxyphosphinyl}-(L)leucinate 
• 561007-47-4 methyl N-{[1-(N'-benzyloxycarbonylamino)-3-methylbutyl]-methoxyphosphinyl}glycinate 

Relevant academic research and scientific papers

The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity

A new class of very potent inhibitors of cytosol leucine aminopeptidase (LAP), a member of the metalloprotease family, is described. The X-ray structure of bovine lens leucine aminopeptidase complexed with the phosphonic acid analogue of leucine (LeuP) wa

Macrocyclic inhibitors of penicillopepsin. 3. Design, synthesis and evaluation of an inhibitor bridged between P2 and P1'

Through application of a thorough design and modeling protocol, the macrocyclic peptidyl phosphonate 5 was derived from the bound structure of an acyclic inhibitor of penicillopepsin, 4, by linking the P1' and P2 side chains; the acyclic analogues 6 and 7

Potent Inhibition of Pepsin and Penicillopepsin by Phosphorus-Containing Peptide Analogues

Phosphinic and phosphonic acid peptide derivatives have been evaluated as inhibitors of the aspartic proteases pepsin and penicillopepsin.The most potent of those studied is isovaleryl-Val-Val-LeuP-(O)Phe-Ala-Ala-OMe (4) (LeuP repres

AN ANALYSIS OF THE ENZYME-INHIBITOR BINDING INTERACTIONS FOR PHOSPHONIC ACID TRANSITION STATE ANALOGS OF THERMOLYSIN

Potent inhibitors of the zinc endopeptidase thermolysin are produced on replacement of the scissile peptide linkage with phosphonamidate or phosphonate ester moieties.These inhibitors have been shown to be transition state analogs, and a comparison betwee