3-[4-({3-[(dimethylamino)sulfonyl]benzyl}oxy)phenyl]-3-ethoxypropionic acid

Base Information

Chemical Name:3-[4-({3-[(dimethylamino)sulfonyl]benzyl}oxy)phenyl]-3-ethoxypropionic acid
CAS No.:1202575-28-7
Molecular Formula:C₂₀H₂₅NO₆S
Molecular Weight:407.488
Hs Code.:

Synonyms:3-[4-({3-[(dimethylamino)sulfonyl]benzyl}oxy)phenyl]-3-ethoxypropionic acid

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Chemical Property of 3-[4-({3-[(dimethylamino)sulfonyl]benzyl}oxy)phenyl]-3-ethoxypropionic acid

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Technology Process of 3-[4-({3-[(dimethylamino)sulfonyl]benzyl}oxy)phenyl]-3-ethoxypropionic acid

There total 6 articles about 3-[4-({3-[(dimethylamino)sulfonyl]benzyl}oxy)phenyl]-3-ethoxypropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1202576-79-1
Ethyl 3-[4-({3-[(dimethylamino)sulfonyl]benzyl}oxy)phenyl]-3-ethoxypropionate

: 1202575-28-7
3-[4-({3-[(dimethylamino)sulfonyl]benzyl}oxy)phenyl]-3-ethoxypropionic acid

Guidance literature:: Ethyl 3-[4-({3-[(dimethylamino)sulfonyl]benzyl}oxy)phenyl]-3-ethoxypropionate; With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 4h;

With hydrogenchloride; In water;

Reference yield:

: 120743-99-9
p-[(tert-butyldimethylsilyl)oxy]benzaldehyde

: 1202575-28-7
3-[4-({3-[(dimethylamino)sulfonyl]benzyl}oxy)phenyl]-3-ethoxypropionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

2: silver(l) oxide / toluene / 20 - 100 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

4: potassium carbonate / acetone / 20 - 60 °C / Inert atmosphere

5: sodium hydroxide; water / ethanol; tetrahydrofuran / 4 h / 20 °C

With tetrabutyl ammonium fluoride; water; potassium carbonate; sodium hydroxide; silver(l) oxide; In tetrahydrofuran; ethanol; acetone; toluene;

Reference yield:

: 1899-93-0
3-methylphenylsulfonyl chloride

: 1202575-28-7
3-[4-({3-[(dimethylamino)sulfonyl]benzyl}oxy)phenyl]-3-ethoxypropionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / tetrahydrofuran / 0 - 20 °C

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

3: potassium carbonate / acetone / 20 - 60 °C / Inert atmosphere

4: sodium hydroxide; water / ethanol; tetrahydrofuran / 4 h / 20 °C

With pyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; potassium carbonate; sodium hydroxide; In tetrahydrofuran; tetrachloromethane; ethanol; acetone;