1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine hydrochloride

Base Information

• Chemical Name: 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine hydrochloride
• CAS No.: 1450657-34-7
• Molecular Formula: C₁₂H₁₇NO₄S*ClH
• Molecular Weight: 307.798
• Mol file: 1450657-34-7.mol

Synonyms:1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine hydrochloride

Chemical Property of 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine hydrochloride

There total 2 articles about 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethen-1-amine (1450657-31-4) → 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine hydrochloride (1450657-34-7)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 1h;

Reference yield:

3-ethoxy-4-methoxybenzenecarbonitrile (60758-86-3) → 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine hydrochloride (1450657-34-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 - 5 °C

1.2: 2 h / 0 - 30 °C

2.1: hydrogenchloride / 1 h / 20 °C

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; hexane;

Reference yield:

1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine hydrochloride (1450657-34-7) → (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine hydrochloride (1450657-15-4) + (R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine hydrochloride (1450657-18-7)

Guidance literature:

With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-(-)-4,12-bis(diphenylphosphino)-[2,2]-paracyclophane; hydrogen; In 2,2,2-trifluoroethanol; at 50 ℃; for 18h; under 5414.51 Torr; Reagent/catalyst; Inert atmosphere;

upstream raw materials:

1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethen-1-amine

3-ethoxy-4-methoxybenzenecarbonitrile

Downstream raw materials:

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine hydrochloride

(R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine hydrochloride