1450657-31-4

Usage

Type of compound

Ethenamine derivative

Structure

Substituted phenyl group and a methylsulfonyl group

Potential applications

Organic synthesis and pharmaceutical research

Safety precautions

Handle and use with proper safety measures and under the guidance of an experienced professional

Upstream product

• 121-32-4 4-hydroxy-3-ethoxybenzaldehyde 
• 60758-79-4 3-ethoxy-4-hydroxybenzonitrile 
• 608142-27-4 (R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)-ethylamine 

Downstream Products

• 253168-94-4 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine 
• 1579992-23-6 C₁₂H₁₆⁽²⁾H₃NO₄S 
• 1579992-22-5 C₁₂H₁₇⁽²⁾H₂NO₄S 
• 1386387-84-3 (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)[1-²H]ethanamine 
• 635705-76-9 7-amino-2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]isoindolin-1-one 
• 1227368-31-1 (1S)-7-nitro-2-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)-ethyl]isoindolin-1-one 
• 608141-41-9 Apremilast 
• 608142-27-4 (R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)-ethylamine 
• 1450657-34-7 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine hydrochloride 
• 608141-42-0 (S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine 
• 608141-43-1 (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate 

Relevant academic research and scientific papers

IMPROVED PROCESS FOR THE PREPARATION OF APREMILAST

The present invention relates to an improved process for the preparation of Apremilast of formula (I).

PROCESS FOR PREPARATION OF APREMILAST AND ITS INTERMEDIATES

Present application relates to the process for the preparation of 1-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethylamine of the formula (II), its resolution and its use in preparation of Apremilast of formula (I), process for the preparation of crystalline form B of apremilast, process for preparation of amorphous form of apremilast and the crystalline form of (S)-1-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethylamine of the formula (Va).