ethyl 4-(2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)acetamido)benzoate

Base Information

Chemical Name:ethyl 4-(2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)acetamido)benzoate
CAS No.:1259007-32-3
Molecular Formula:C₁₉H₁₆Cl₂N₄O₃S
Molecular Weight:451.333
Hs Code.:

Synonyms:ethyl 4-(2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)acetamido)benzoate

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Chemical Property of ethyl 4-(2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)acetamido)benzoate

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Technology Process of ethyl 4-(2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)acetamido)benzoate

There total 5 articles about ethyl 4-(2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)acetamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.4%

: 1338831-07-4
2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)acetic acid

: 94-09-7
p-aminoethylbenzoate

: 1259007-32-3
ethyl 4-(2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)acetamido)benzoate

Guidance literature:: 2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)acetic acid; With phosphorus pentachloride; In diethyl ether; at 20 ℃; for 2h; Cooling with ice;

p-aminoethylbenzoate; With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2011.08.011

Reference yield:

: 106103-85-9
2-(2-(2,4-dichlorophenyl)hydrazono)acetic acid

: 1259007-32-3
ethyl 4-(2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)acetamido)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / toluene / 1 h / Reflux

2.1: trichlorophosphate / 10 h / Reflux

3.1: sodium hydride / tetrahydrofuran / 8.17 h / 0 °C / Reflux

4.1: sodium hydroxide / water; dimethyl sulfoxide / 1 h / 20 °C

5.1: phosphorus pentachloride / diethyl ether / 2 h / 20 °C / Cooling with ice

5.2: 2 h / 20 °C

With phosphorus pentachloride; sodium hydride; triethylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; diethyl ether; water; dimethyl sulfoxide; toluene;
DOI:10.1016/j.ejmech.2011.08.011

Reference yield:

: 1259007-33-4
5-chloro-1-(2,4-dichlorophenyl)-1H-1,2,4-triazole

: 1259007-32-3
ethyl 4-(2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)acetamido)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 8.17 h / 0 °C / Reflux

2.1: sodium hydroxide / water; dimethyl sulfoxide / 1 h / 20 °C

3.1: phosphorus pentachloride / diethyl ether / 2 h / 20 °C / Cooling with ice

3.2: 2 h / 20 °C

With phosphorus pentachloride; sodium hydride; sodium hydroxide; In tetrahydrofuran; diethyl ether; water; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.08.011