2-[bis(tert-butoxycarbonyl)amino]-6-(4-methoxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester

Base Information

Chemical Name:2-[bis(tert-butoxycarbonyl)amino]-6-(4-methoxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester
CAS No.:836599-08-7
Molecular Formula:C₂₉H₃₆F₆N₅O₉PS
Molecular Weight:775.663
Hs Code.:

Synonyms:2-[bis(tert-butoxycarbonyl)amino]-6-(4-methoxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester

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Chemical Property of 2-[bis(tert-butoxycarbonyl)amino]-6-(4-methoxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester

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Technology Process of 2-[bis(tert-butoxycarbonyl)amino]-6-(4-methoxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester

There total 7 articles about 2-[bis(tert-butoxycarbonyl)amino]-6-(4-methoxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 836599-06-5
2-[bis(tert-butoxycarbonyl)amino]-6-(4-hydroxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester

: 24424-99-5
di-tert-butyl dicarbonate

: 836599-08-7
2-[bis(tert-butoxycarbonyl)amino]-6-(4-methoxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester

Guidance literature:: With dmap; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmc.2004.10.007

Reference yield:

: 836599-04-3
2-[bis(tert-butoxycarbonyl)amino]-6-chloro-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester

: 836599-08-7
2-[bis(tert-butoxycarbonyl)amino]-6-(4-methoxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 31 percent / pyridine / dimethylformamide / 5 h / 60 °C

2: 45 percent / DMAP / tetrahydrofuran / 20 °C

With pyridine; dmap; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.10.007

Reference yield:

: 637-89-8
4-sulfanylphenol

: 836599-08-7
2-[bis(tert-butoxycarbonyl)amino]-6-(4-methoxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 31 percent / pyridine / dimethylformamide / 5 h / 60 °C

2: 45 percent / DMAP / tetrahydrofuran / 20 °C

With pyridine; dmap; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.10.007