(2R,8S,9R,10S,13S)-13-(3-Benzyloxy-phenyl)-2-[2-(2,2-dimethoxy-ethyl)-[1,3]dithian-2-yl]-13-methoxy-9-methoxymethoxy-4,4,8,10-tetramethyl-tridec-6-yn-5-one

Base Information

Chemical Name:(2R,8S,9R,10S,13S)-13-(3-Benzyloxy-phenyl)-2-[2-(2,2-dimethoxy-ethyl)-[1,3]dithian-2-yl]-13-methoxy-9-methoxymethoxy-4,4,8,10-tetramethyl-tridec-6-yn-5-one
CAS No.:159751-75-4
Molecular Formula:C₄₁H₆₀O₇S₂
Molecular Weight:729.055
Hs Code.:

(2R,8S,9R,10S,13S)-13-(3-Benzyloxy-phenyl)-2-[2-(2,2-dimethoxy-ethyl)-[1,3]dithian-2-yl]-13-methoxy-9-methoxymethoxy-4,4,8,10-tetramethyl-tridec-6-yn-5-one

Synonyms:(2R,8S,9R,10S,13S)-13-(3-Benzyloxy-phenyl)-2-[2-(2,2-dimethoxy-ethyl)-[1,3]dithian-2-yl]-13-methoxy-9-methoxymethoxy-4,4,8,10-tetramethyl-tridec-6-yn-5-one

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Chemical Property of (2R,8S,9R,10S,13S)-13-(3-Benzyloxy-phenyl)-2-[2-(2,2-dimethoxy-ethyl)-[1,3]dithian-2-yl]-13-methoxy-9-methoxymethoxy-4,4,8,10-tetramethyl-tridec-6-yn-5-one

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Technology Process of (2R,8S,9R,10S,13S)-13-(3-Benzyloxy-phenyl)-2-[2-(2,2-dimethoxy-ethyl)-[1,3]dithian-2-yl]-13-methoxy-9-methoxymethoxy-4,4,8,10-tetramethyl-tridec-6-yn-5-one

There total 14 articles about (2R,8S,9R,10S,13S)-13-(3-Benzyloxy-phenyl)-2-[2-(2,2-dimethoxy-ethyl)-[1,3]dithian-2-yl]-13-methoxy-9-methoxymethoxy-4,4,8,10-tetramethyl-tridec-6-yn-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: (2R,8S,9R,10S,13S)-13-(3-Benzyloxy-phenyl)-2-[2-(2,2-dimethoxy-ethyl)-[1,3]dithian-2-yl]-13-methoxy-9-methoxymethoxy-4,4,8,10-tetramethyl-tridec-6-yn-5-ol

: 159751-75-4
(2R,8S,9R,10S,13S)-13-(3-Benzyloxy-phenyl)-2-[2-(2,2-dimethoxy-ethyl)-[1,3]dithian-2-yl]-13-methoxy-9-methoxymethoxy-4,4,8,10-tetramethyl-tridec-6-yn-5-one

Guidance literature:: With pyridine-SO₃ complex; dimethyl sulfoxide; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(00)73355-7

Reference yield:

: 159751-62-9
(R)-5-Benzyloxymethoxy-2,2,4-trimethyl-pentanoic acid ethyl ester

: 159751-75-4
(2R,8S,9R,10S,13S)-13-(3-Benzyloxy-phenyl)-2-[2-(2,2-dimethoxy-ethyl)-[1,3]dithian-2-yl]-13-methoxy-9-methoxymethoxy-4,4,8,10-tetramethyl-tridec-6-yn-5-one

Guidance literature:: Multi-step reaction with 10 steps

1: 92 percent / H₂ / Pd-black / ethanol

2: (COCl)2, Et₃N, DMSO / CH₂Cl₂

3: BF₃*OEt₂ / CH₂Cl₂

4: 93 percent / LiAlH₄ / diethyl ether

5: 98 percent / imidazole / dimethylformamide

6: 99 percent / t-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide

7: 93 percent / n-Bu₄NF / tetrahydrofuran

8: 92 percent / SO₃*pyridine, Et₃N, DMSO / CH₂Cl₂

9: 93 percent / n-BuLi / tetrahydrofuran

10: 87 percent / SO₃*pyridine, DMSO, Et₃N / CH₂Cl₂

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; pyridine-SO₃ complex; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; tert.-butyl lithium; dimethyl sulfoxide; triethylamine; palladium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)73355-7

Reference yield:

: 159751-65-2
(R)-4-[1,3]Dithian-2-yl-2,2-dimethyl-pentan-1-ol

: 159751-75-4
(2R,8S,9R,10S,13S)-13-(3-Benzyloxy-phenyl)-2-[2-(2,2-dimethoxy-ethyl)-[1,3]dithian-2-yl]-13-methoxy-9-methoxymethoxy-4,4,8,10-tetramethyl-tridec-6-yn-5-one

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / imidazole / dimethylformamide

2: 99 percent / t-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide

3: 93 percent / n-Bu₄NF / tetrahydrofuran

4: 92 percent / SO₃*pyridine, Et₃N, DMSO / CH₂Cl₂

5: 93 percent / n-BuLi / tetrahydrofuran

6: 87 percent / SO₃*pyridine, DMSO, Et₃N / CH₂Cl₂

With 1H-imidazole; n-butyllithium; pyridine-SO₃ complex; tetrabutyl ammonium fluoride; tert.-butyl lithium; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)73355-7